P.41 Measurement of Pressure-dependent Intra-Beat Changes in Carotid Pulse Wave Velocity using Image-Free Fast Ultrasound
- 10.2991/artres.k.201209.053How to use a DOI?
- Fast-ultrasound; incremental-PWV; image-free ultrasound
Background: The clinical significance of pressure-dependent intra-beat changes in local pulse-wave velocity (C) has recently come to light . While reported methods require arterial pressure and diameter measurements from a single site to assess intra-beat changes in C, we present an image-free fast ultrasound device that performs this by capturing diameter waveforms from two proximal locations on an artery..
Methods: The functionality was assessed on eight normotensive participants (26 ± 4 years). By perturbing blood pressure through a short duration moderate lower body negative pressure intervention , CD and CF pulse wave velocities corresponding to diastolic and 80% of peak pressure were measured from the carotid artery. Human NIBP system (ADInstruments, India) was used for monitoring continuous pressure.
Results: The device captured dual-diameter waveforms and evaluated CD and CF, with a beat-to-beat variation <8% during baseline. CD was smaller than CF (p < 0.001), 4.2 ± 0.5 m/s versus 4.6 ± 0.7 m/s during baseline and 3.7 ± 0.6 m/s versus 3.9 ± 0.7 m/s during intervention. Concomitant to the drop in group-average diastolic (17%) and systolic (18%) pressures during the intervention, CD and CF dropped by 14% and 16%, respectively. The statistically significant correlation (r > 0.6, p < 0.001) of CD and CF with the diastolic and systolic pressures for each individual was preserved even after adjusting for heart-rate.
Conclusions: The device demonstrated its functionality and reliably measured the incremental nature of C. Its pressure-dependent intra-beat variations and inter-beat dynamics during the intervention concurred with literature. Further studies are underway to demonstrate the potential use of the device in vascular research and clinical applications.
- © 2020 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.
- Open Access
- This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).
Cite this article
TY - JOUR AU - Kiran V Raj AU - P M Nabeel AU - Jayaraj Joseph AU - Dinu Chandran AU - Mohanasankar Sivaprakasam PY - 2020 DA - 2020/12/31 TI - P.41 Measurement of Pressure-dependent Intra-Beat Changes in Carotid Pulse Wave Velocity using Image-Free Fast Ultrasound JO - Artery Research SP - S63 EP - S63 VL - 26 IS - Supplement 1 SN - 1876-4401 UR - https://doi.org/10.2991/artres.k.201209.053 DO - 10.2991/artres.k.201209.053 ID - Raj2020 ER -