P.18 Carotid Stiffness Parameters and Cerebral Blood Flow Pulsatility in Young Healthy Individuals across Races
- 10.2991/artres.k.201209.031How to use a DOI?
- Carotid compliance; transcranial; ultrasound
Background: Higher cerebral blood flow (CBF) pulsatility was found to be associated with severer brain white matter lesions in the elderly . It was hypothesized that the central/elastic arterial stiffness/compliance may directly affect CBF pulsatility. However, it is still unclear which carotid stiffness parameters may better reflect this impact, and whether race and sex differences are present.
Methods: To study the correlations among those parameters with comparisons between different races and sexes, we enrolled 35 young healthy subjects (19 females), aged 29 ± 5 (18∼40) years, with three races of comparable age and sex ratio, i.e. White (n = 16), Black (n = 7), and Asian (n = 12). All subjects were in resting seated position, with continuous transcranial Doppler recording of CBF velocity at middle cerebral artery (MCA), simultaneous 1-min ultrasound echo-tracking on bilateral common carotid arteries, and multiple measurements of brachial blood pressure (BP).
Results: All derived parameters , including MCA pulsatility index (PI), showed no significant racial differences but with significantly (p < 0.05) higher carotid stiffness index (β), Peterson’s pressure modulus (Ep), BP pulsatility index (mostly driven by higher systolic BP but similar diastolic BP), and lower arterial compliance (AC, p = 0.07) in males than in females. Only AC (but not β and Ep) showed a significant correlation with PI (r = 0.49, p = 0.004) even after controlling for BP pulsatility index, which negatively correlated with AC (ρ = −0.35, p = 0.038).
Conclusions: Higher carotid AC (i.e. decreased stiffness) seems to enhance CBF pulsatility in young healthy populations, which might differ from the elderly.
- © 2020 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.
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- This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).
Cite this article
TY - JOUR AU - Jie Liu AU - Michelle E. Favre AU - Stephanie G. Iring AU - Allan Knox AU - Jorge M. Serrador PY - 2020 DA - 2020/12/31 TI - P.18 Carotid Stiffness Parameters and Cerebral Blood Flow Pulsatility in Young Healthy Individuals across Races JO - Artery Research SP - S40 EP - S40 VL - 26 IS - Supplement 1 SN - 1876-4401 UR - https://doi.org/10.2991/artres.k.201209.031 DO - 10.2991/artres.k.201209.031 ID - Liu2020 ER -