Clinical Hematology International

Volume 1, Issue 1, March 2019, Pages 28 - 35

Fecal Microbiota Transplantation for Treatment of Acute Graft-versus-Host Disease

Authors
Roni Shouval1, 2, *, Mika Geva1, Arnon Nagler1, Ilan Youngster3
1 Hematology and Bone Marrow Transplantation Division, Chaim Sheba Medical Center, Tel-Hashomer, Sackler School of Medicine, Tel Aviv University, Ramat-Gan, Israel
2 Dr. Pinchas Bornstein Talpiot Medical Leadership Program, Chaim Sheba Medical Center, Ramat-Gan, Israel
3 Pediatric Division and Microbiome Research Center, Assaf Harofeh Medical Center, affiliated with Tel Aviv University, Zerifin, Israel

Peer review is under the responsibility of IACH

*Corresponding author. E-mail: shouval@gmail.com
Corresponding Author
Roni Shouval
Received 12 February 2019, Accepted 4 March 2019, Available Online 18 April 2019.
DOI
https://doi.org/10.2991/chi.d.190316.002How to use a DOI?
Keywords
Hematopoietic stem cell transplantation, Graft-versus-host disease, Microbiome, Fecal microbiota transplantation
Abstract

The growing understanding of the bidirectional relationship between the gastrointestinal (GI) microbiome and the immune system has opened up new avenues for treatment of graft-versus-host disease (GVHD). Fecal microbiota transplantation (FMT) is the transfer of stool from a donor to a recipient who harbors a perturbed GI microbiome resulting in disease. We review the rationale for performing FMT for the treatment of acute GVHD, and summarize data on the safety and efficacy of the procedure among allogeneic hematopoietic stem cell transplantation (HSCT) recipients. Overall, FMT is a promising strategy in treating and preventing HSCT-related complications. However, caution should be exerted as HSCT recipients are highly immunosuppressed and unanticipated infectious adverse events may appear with the increasing application of FMT.

Copyright
© 2019 International Academy for Clinical Hematology. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

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Journal
Clinical Hematology International
Volume-Issue
1 - 1
Pages
28 - 35
Publication Date
2019/04/18
ISSN (Online)
2590-0048
DOI
https://doi.org/10.2991/chi.d.190316.002How to use a DOI?
Copyright
© 2019 International Academy for Clinical Hematology. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

TY  - JOUR
AU  - Roni Shouval
AU  - Mika Geva
AU  - Arnon Nagler
AU  - Ilan Youngster
PY  - 2019
DA  - 2019/04/18
TI  - Fecal Microbiota Transplantation for Treatment of Acute Graft-versus-Host Disease
JO  - Clinical Hematology International
SP  - 28
EP  - 35
VL  - 1
IS  - 1
SN  - 2590-0048
UR  - https://doi.org/10.2991/chi.d.190316.002
DO  - https://doi.org/10.2991/chi.d.190316.002
ID  - Shouval2019
ER  -