Clinical Hematology International

Volume 1, Issue 1, March 2019, Pages 36 - 44

Challenges in Conducting Studies in Chronic Graft-versus-Host Disease

Authors
Iskra Pusic1, *, Steven Z. Pavletic2
1Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri
2National Institutes of Health, National Cancer Institute, Center for Cancer Research, Bethesda, Maryland

Peer review is under the responsibility of IACH

*Corresponding author. Email: iskrapusic@wustl.edu
Corresponding Author
Iskra Pusic
Received 8 March 2019, Accepted 10 March 2019, Available Online 18 March 2019.
DOI
https://doi.org/10.2991/chi.d.190314.001How to use a DOI?
Keywords
GvHD; GRFS; FFS; Response criteria; Composite endpoints
Abstract

The lack of standardized criteria for measuring therapeutic response has been a major obstacle to the development of therapeutic trials in chronic graft-versus-host disease (cGvHD). Nevertheless, recent advances have been made in understanding of the biology and pathophysiology of cGvHD, as well as establishing more precise criteria for the diagnosis and classification of disease manifestations. The momentum has shifted, and currently there is a long list of new potential treatment targets being identified for cGvHD. Consequently, new drugs are being implemented for its prophylaxis and treatment. It is crucial to continue that trend and develop better systems to test new drugs in clinical practice that would eventually translate toward seeking regulatory review and approval. We provide a historical perspective and current challenges in conducting cGvHD clinical trials.

Copyright
© 2019 International Academy for Clinical Hematology. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

Download article (PDF)
View full text (HTML)

Journal
Clinical Hematology International
Volume-Issue
1 - 1
Pages
36 - 44
Publication Date
2019/03/18
ISSN (Online)
2590-0048
DOI
https://doi.org/10.2991/chi.d.190314.001How to use a DOI?
Copyright
© 2019 International Academy for Clinical Hematology. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

TY  - JOUR
AU  - Iskra Pusic
AU  - Steven Z. Pavletic
PY  - 2019
DA  - 2019/03/18
TI  - Challenges in Conducting Studies in Chronic Graft-versus-Host Disease
JO  - Clinical Hematology International
SP  - 36
EP  - 44
VL  - 1
IS  - 1
SN  - 2590-0048
UR  - https://doi.org/10.2991/chi.d.190314.001
DO  - https://doi.org/10.2991/chi.d.190314.001
ID  - Pusic2019
ER  -