Clinical Hematology International

Volume 1, Issue 1, March 2019, Pages 45 - 51

Endothelial Dysfunction in Hematopoietic Cell Transplantation

Authors
Marta Palomo1, 2, 3, *, Maribel Diaz-Ricart2, 3, Enric Carreras1, 3
1 Josep Carreras Leukaemia Research Institute, Hospital Clinic/University of Barcelona Campus, Barcelona, Spain
2 Hematopathology, Department of Pathology, Hospital Clinic of Barcelona, Biomedical Diagnosis Center (CDB), Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain
3 Barcelona Endothelium Team

Peer review is under the responsibility of IACH

*Corresponding author. Email: mpalomo@carrerasresearch.org
Corresponding Author
Marta Palomo
Received 8 March 2019, Accepted 14 March 2019, Available Online 18 March 2019.
DOI
https://doi.org/10.2991/chi.d.190317.001How to use a DOI?
Keywords
Endohtelium, Hematopoietic stem cell transplantation, Endothelial dysfunction, Inflammation, GvHD, TA-TMA
Abstract

The goal of this review is to look at the role of endothelial damage and dysfunction in the initiation and development of early complications that appear after hematopoietic cell transplantation (HCT). These early complications share overlapping clinical manifestations and the suspicion of underlying endothelial damage. Several studies using different approaches, such as animal and in vitro models, the analysis of soluble biomarkers and clinical findings have provided evidence of this endothelial dysfunction. Historically, the first complication in which the role of endothelial damage was elucidated was the veno-oclusive disease/sinusoidal obstructive syndrome. In the last two decades, increasing evidence of the implication of the endothelium in the pathophysiology of other syndromes such as capillary leak syndrome, transplant-associated microangiopathy, or even graft versus host disease has accumulated. This knowledge opens up potential pharmacologic interventions to prevent/and/or treat endothelial damage and, therefore, to improve the outcome of patients receiving HCT.

Copyright
© 2019 International Academy for Clinical Hematology. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

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Journal
Clinical Hematology International
Volume-Issue
1 - 1
Pages
45 - 51
Publication Date
2019/03/18
ISSN (Online)
2590-0048
DOI
https://doi.org/10.2991/chi.d.190317.001How to use a DOI?
Copyright
© 2019 International Academy for Clinical Hematology. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

TY  - JOUR
AU  - Marta Palomo
AU  - Maribel Diaz-Ricart
AU  - Enric Carreras
PY  - 2019
DA  - 2019/03/18
TI  - Endothelial Dysfunction in Hematopoietic Cell Transplantation
JO  - Clinical Hematology International
SP  - 45
EP  - 51
VL  - 1
IS  - 1
SN  - 2590-0048
UR  - https://doi.org/10.2991/chi.d.190317.001
DO  - https://doi.org/10.2991/chi.d.190317.001
ID  - Palomo2019
ER  -