Idiopathic Aplastic Anemia: An Update
- 10.2991/chi.d.190321.002How to use a DOI?
- Acquired aplastic anemia; Bone marrow failure
“Bone marrow failure” encompass all the conditions and syndromes in which there are qualitative or quantitative disorders of one or more lineages (erythroid, myelomonocytic, and/or megakaryocytic). A few years ago, the pathophysiology of these syndromes was completely unknown. Today we have better knowledge for these diseases, allowing the development of new treatment options and the improvement of patients' outcome. Acquired bone marrow failure syndromes include myelodysplastic syndromes, aplastic anemia, paroxysmal nocturnal hemoglobinuria, idiopathic neutropenia and large granular leukemia. All these syndromes share some common features and pathophysiology. The most important feature is the possibility of clonal evolution and progression into acute myelogenous leukemia, and open questions still remain on how to prevent evolution in these patients.
- © 2019 International Academy for Clinical Hematology. Publishing services by Atlantis Press International B.V.
- Open Access
- This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).
Cite this article
TY - JOUR AU - Elena E. Solomou PY - 2019 DA - 2019/04/01 TI - Idiopathic Aplastic Anemia: An Update JO - Clinical Hematology International SP - 52 EP - 57 VL - 1 IS - 1 SN - 2590-0048 UR - https://doi.org/10.2991/chi.d.190321.002 DO - 10.2991/chi.d.190321.002 ID - Solomou2019 ER -