High Sensitivity Troponin T and NT-proBNP in Patients Receiving Chimeric Antigen Receptor (CAR) T-Cell Therapy
Division of Cardiovascular Medicine, Yale School of Medicine, New Haven, CT, USA
- https://doi.org/10.2991/chi.k.210718.001How to use a DOI?
- Chimeric antigen receptor T cell; troponin; BNP; cardiotoxicity; lymphoma
Retrospective studies suggest that chimeric antigen receptor T-cell (CAR T) therapy may lead to cardiac injury, but this has not been assessed systematically or prospectively. In this prospective study of 40 patients who received CAR T, we systematically measured high-sensitivity troponin T (hsTropT) and N-terminal pro-B natriuretic peptide (NTproBNP) at baseline and on day 1, days 7, and 21 after CAR T. Biomarker elevations with respect to timepoint and cytokine release syndrome (CRS) status were examined using repeated measure analysis of variance. hsTropT did not differ with time or with the presence of grade 2 CRS. Median hsTropT was 12.1 ng/L [interquartile range (IQR): 9.2, 20.1] at baseline, 13.1 ng/L (IQR: 9.6, 24.2) at day 1, 11.9 ng/L (IQR: 9.6, 18.0) at day 7, and 15.3 ng/L (10.8, 20.2) at day 21. In contrast, NTproBNP rose on day 1 (PWilcox = 0.0002) and day 7 (PWilcox = 2.7 × 10−5), and the degree of elevation differed by the presence of grade 2 CRS (Pinteraction = 0.002). Median NTproBNP was 179 pg/mL (IQR: 116, 325) at baseline, 357 pg/mL (IQR: 98, 813) at day 1, 420 pg/mL (IQR: 239, 1242) at day 7, and 177 pg/mL (IQR: 80, 278) at day 21. In conclusion, hsTropT l did not differ across timepoints after CAR T therapy, but NTproBNP rose at day 7, the prognostic implications of which should be the target of future research, as the indications for this therapy expand.
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- Open Access
- This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).
Cite this article
TY - JOUR AU - Jiun-Ruey Hu AU - Ameet Patel AU - Shi Huang AU - Yan Ru Su AU - Kimberly B. Dahlman AU - Kelsey Tomasek AU - Yueli Zhang AU - Richard T. O’Neil AU - Jamye F. O’Neal AU - Isik Turker AU - Douglas B. Johnson AU - Joe-Elie Salem AU - Javid J. Moslehi AU - Olalekan Oluwole PY - 2021 DA - 2021/08/02 TI - High Sensitivity Troponin T and NT-proBNP in Patients Receiving Chimeric Antigen Receptor (CAR) T-Cell Therapy JO - Clinical Hematology International SP - 96 EP - 102 VL - 3 IS - 3 SN - 2590-0048 UR - https://doi.org/10.2991/chi.k.210718.001 DO - https://doi.org/10.2991/chi.k.210718.001 ID - Hu2021 ER -