Proceedings of The 13th Annual Scientific Conference of Medical Faculty, Universitas Jenderal Achmad Yani (ASCMF 2022)

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The Influence of Plum (Prunus salicina Lindl) Extract to Liver MDA Levels in Rats Induced by High Fat Diet

Authors
Hendri Priyadi1, *, Indarti Trimurtini2, Fransiska Ambarukmi Pontjosudargo2
1Department of Internal Medicine, Faculty of Medicine, University of Jenderal Achmad Yani, Cimahi, Indonesia
2Department of Anatomy, Faculty of Medicine, University of Jenderal Achmad Yani, Cimahi, Indonesia
*Corresponding author. Email: henpri74.hp@gmail.com
Corresponding Author
Hendri Priyadi
Available Online 16 December 2022.
DOI
10.2991/978-94-6463-060-2_19How to use a DOI?
Keywords
High fat diet; Liver MDA; Plum
Abstract

This observation was performed to evaluate the effect of Plum extract on liver damage with indicators of MDA levels in male rats. The goal of this study was to obtain the benefits of herbal elements such as hepatoprotection in rats induced by an excessive-fat diet. A high-fat diet is expected to produce a state of fatty liver with the aid of increasing the liver MDA. This study is a laboratory observation with a very randomized design, the use of 25 samples which had been grouped into five organizations which includes five rats, which are a negative group, a positive group, and three treatment groups who were given ethanol extract of plum dose of 0,8 mg/kg BW/day, 1,6 mg/kg BW/day and 2,4 mg/kg BW/day. The negative group was only given standard pellets while the positive group were given a high-fat diet and induced by propylthiouracil. The indicator that will be assessed is the liver MDA. The data obtained were analyzed using analysis of variance (ANOVA) and further tests were carried out with Duncan's test. The consequences confirmed that the liver MDA levels in the group given Plum fruit extract at doses of 0.8 mg/kg BW and 1.6 mg/kg BW were significantly lower than the positive control group. Plum fruit extract was able to inhibit the increase in liver MDA levels at an effective dose of 0.8 mg/kg BW.

Copyright
© 2023 The Author(s)
Open Access
Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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Volume Title
Proceedings of The 13th Annual Scientific Conference of Medical Faculty, Universitas Jenderal Achmad Yani (ASCMF 2022)
Series
Advances in Health Sciences Research
Publication Date
16 December 2022
ISBN
10.2991/978-94-6463-060-2_19
ISSN
2468-5739
DOI
10.2991/978-94-6463-060-2_19How to use a DOI?
Copyright
© 2023 The Author(s)
Open Access
Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

Cite this article

risenwbib
TY  - CONF
AU  - Hendri Priyadi
AU  - Indarti Trimurtini
AU  - Fransiska Ambarukmi Pontjosudargo
PY  - 2022
DA  - 2022/12/16
TI  - The Influence of Plum (Prunus salicina Lindl) Extract to Liver MDA Levels in Rats Induced by High Fat Diet
BT  - Proceedings of The 13th Annual Scientific Conference of Medical Faculty, Universitas Jenderal Achmad Yani (ASCMF 2022)
PB  - Atlantis Press
SP  - 134
EP  - 138
SN  - 2468-5739
UR  - https://doi.org/10.2991/978-94-6463-060-2_19
DO  - 10.2991/978-94-6463-060-2_19
ID  - Priyadi2022
ER  -