Proceedings of the 2nd International Conference on Biomedical and Biological Engineering 2017 (BBE 2017)

Twin-Studies on the Role of Non-Genetic Factors in T1D Pathogenesis

Authors
Li-li MA, Yan-ling WU, Ying DONG, Yoshimasa TANAKA, Wen ZHANG
Corresponding Author
Li-li MA
Available Online May 2017.
DOI
https://doi.org/10.2991/bbe-17.2017.57How to use a DOI?
Keywords
Type 1 Diabetes (T1d), Twin-Study, Epigenetic Mechanism, Immunity, Complications.
Abstract
Type 1 diabetes (T1D) is a complex autoimmune disease characterized by T cell-mediated destruction of pancreatic cells, which is resulted from the interaction of genetic and environmental factors. Twin-study is one of the most important methods to identify the genetic basis of complex diseases or traits as well as the influence of non-genetic factors in the pathogenesis of T1D. This article summarizes recent twin-studies about the role of non-genetic factors in T1D pathogenesis, including epigenetic mechanism, immunity, and complication factors. In addition, we discuss the potential necessity of the twin-study method in the research on the influence of the living environment on T1D.
Open Access
This is an open access article distributed under the CC BY-NC license.

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Proceedings
2nd International Conference on Biomedical and Biological Engineering 2017 (BBE 2017)
Part of series
Advances in Biological Sciences Research
Publication Date
May 2017
ISBN
978-94-6252-362-3
ISSN
2468-5747
DOI
https://doi.org/10.2991/bbe-17.2017.57How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - CONF
AU  - Li-li MA
AU  - Yan-ling WU
AU  - Ying DONG
AU  - Yoshimasa TANAKA
AU  - Wen ZHANG
PY  - 2017/05
DA  - 2017/05
TI  - Twin-Studies on the Role of Non-Genetic Factors in T1D Pathogenesis
BT  - 2nd International Conference on Biomedical and Biological Engineering 2017 (BBE 2017)
PB  - Atlantis Press
SN  - 2468-5747
UR  - https://doi.org/10.2991/bbe-17.2017.57
DO  - https://doi.org/10.2991/bbe-17.2017.57
ID  - MA2017/05
ER  -