Twin-Studies on the Role of Non-Genetic Factors in T1D Pathogenesis
Li-li MA, Yan-ling WU, Ying DONG, Yoshimasa TANAKA, Wen ZHANG
Available Online May 2017.
- 10.2991/bbe-17.2017.57How to use a DOI?
- Type 1 Diabetes (T1d), Twin-Study, Epigenetic Mechanism, Immunity, Complications.
Type 1 diabetes (T1D) is a complex autoimmune disease characterized by T cell-mediated destruction of pancreatic cells, which is resulted from the interaction of genetic and environmental factors. Twin-study is one of the most important methods to identify the genetic basis of complex diseases or traits as well as the influence of non-genetic factors in the pathogenesis of T1D. This article summarizes recent twin-studies about the role of non-genetic factors in T1D pathogenesis, including epigenetic mechanism, immunity, and complication factors. In addition, we discuss the potential necessity of the twin-study method in the research on the influence of the living environment on T1D.
- © 2017, the Authors. Published by Atlantis Press.
- Open Access
- This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).
Cite this article
TY - CONF AU - Li-li MA AU - Yan-ling WU AU - Ying DONG AU - Yoshimasa TANAKA AU - Wen ZHANG PY - 2017/05 DA - 2017/05 TI - Twin-Studies on the Role of Non-Genetic Factors in T1D Pathogenesis BT - Proceedings of the 2nd International Conference on Biomedical and Biological Engineering 2017 (BBE 2017) PB - Atlantis Press SP - 362 EP - 367 SN - 2468-5747 UR - https://doi.org/10.2991/bbe-17.2017.57 DO - 10.2991/bbe-17.2017.57 ID - MA2017/05 ER -