Twin-Studies on the Role of Non-Genetic Factors in T1D Pathogenesis

DOI

10.2991/bbe-17.2017.57How to use a DOI?

Keywords

Type 1 Diabetes (T1d), Twin-Study, Epigenetic Mechanism, Immunity, Complications.

Abstract

Type 1 diabetes (T1D) is a complex autoimmune disease characterized by T cell-mediated destruction of pancreatic cells, which is resulted from the interaction of genetic and environmental factors. Twin-study is one of the most important methods to identify the genetic basis of complex diseases or traits as well as the influence of non-genetic factors in the pathogenesis of T1D. This article summarizes recent twin-studies about the role of non-genetic factors in T1D pathogenesis, including epigenetic mechanism, immunity, and complication factors. In addition, we discuss the potential necessity of the twin-study method in the research on the influence of the living environment on T1D.

Copyright

© 2017, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Li-li MA
AU  - Yan-ling WU
AU  - Ying DONG
AU  - Yoshimasa TANAKA
AU  - Wen ZHANG
PY  - 2017/05
DA  - 2017/05
TI  - Twin-Studies on the Role of Non-Genetic Factors in T1D Pathogenesis
BT  - Proceedings of the 2nd International Conference on Biomedical and Biological Engineering 2017 (BBE 2017)
PB  - Atlantis Press
SP  - 362
EP  - 367
SN  - 2468-5747
UR  - https://doi.org/10.2991/bbe-17.2017.57
DO  - 10.2991/bbe-17.2017.57
ID  - MA2017/05
ER  -