Proceedings of the 2016 International Conference on Biological Engineering and Pharmacy (BEP 2016)

Three Monoterpenoids Eucommiol from The Leaves of Eucommia Ulmoides Protect against Neurotoxicity in PC12 Cells

Authors
Yueming ZUO, Zhongli ZHANG
Corresponding Author
Yueming ZUO
Available Online December 2016.
DOI
10.2991/bep-16.2017.30How to use a DOI?
Keywords
leaves of Eucommia ulmoides; Cyclohexenone; Eucommiol; PC12
Abstract

One new monoterpenoid compound 4'-acetyl-eucommiol (1) and two known compounds eucommiol(2), 1-deoxyeucommiol(3) were isolated from the leaves of Eucommia ulmoides. The structures of the new monoterpenoid eucommiol were elucidated by means of chemical evidence and 1D-and 2D-NMR (1H, 13C, HSQC, HMBC, 1H-1H COSY and NOESY) spectroscopic analysis and HR-ESI-MS. We also investigated the protective effect of compounds 1-3 on the neurotoxicity of PC12 cells induced by amyloid-beta (Aβ 25-35), respectively. As a result, compounds 1 and 2 were seen to afford protection against Aβ-induced toxicity in PC12 cells.

Copyright
© 2017, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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Volume Title
Proceedings of the 2016 International Conference on Biological Engineering and Pharmacy (BEP 2016)
Series
Advances in Biological Sciences Research
Publication Date
December 2016
ISBN
978-94-6252-287-9
ISSN
2468-5747
DOI
10.2991/bep-16.2017.30How to use a DOI?
Copyright
© 2017, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

TY  - CONF
AU  - Yueming ZUO
AU  - Zhongli ZHANG
PY  - 2016/12
DA  - 2016/12
TI  - Three Monoterpenoids Eucommiol from The Leaves of Eucommia Ulmoides Protect against Neurotoxicity in PC12 Cells
BT  - Proceedings of the 2016 International Conference on Biological Engineering and Pharmacy (BEP 2016)
PB  - Atlantis Press
SP  - 143
EP  - 145
SN  - 2468-5747
UR  - https://doi.org/10.2991/bep-16.2017.30
DO  - 10.2991/bep-16.2017.30
ID  - ZUO2016/12
ER  -