Proceedings of the 2016 International Conference on Biological Engineering and Pharmacy (BEP 2016)

Chitosan Derivative Nanoparticles as Prolonged Releasing Drug Carriers

Authors
Bohua FENG, Liufen PENG
Corresponding Author
Bohua FENG
Available Online December 2016.
DOI
https://doi.org/10.2991/bep-16.2017.34How to use a DOI?
Keywords
nanocarrier; chitosan derivative; drug carrier
Abstract

Ricinoleic acid grafted amphiphilic carboxymethy chitosan (CMC-g-RA) was synthesized as a carrier to load botanical drug rotenone (Rot). Then Rot/CMC-g-RA water dispersion in nanoscale was prepared, whose shape, zeta potential, loading efficiency and outdoor stability were characterized accordingly. The results indicated that the sizes, polydispersity index, zeta potential of Rot/CMC-g-RA particles were affected by concentrations of this water dispersion. When the ratio of carrier to drug ascended, the water dispersion had monodisperse nanoparticle sizes with negative charge on nanoparticle surface. And the water dispersion restrained Rot degradation in natural environment with higher loading efficiency.

Copyright
© 2017, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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Volume Title
Proceedings of the 2016 International Conference on Biological Engineering and Pharmacy (BEP 2016)
Series
Advances in Biological Sciences Research
Publication Date
December 2016
ISBN
978-94-6252-287-9
ISSN
2468-5747
DOI
https://doi.org/10.2991/bep-16.2017.34How to use a DOI?
Copyright
© 2017, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

TY  - CONF
AU  - Bohua FENG
AU  - Liufen PENG
PY  - 2016/12
DA  - 2016/12
TI  - Chitosan Derivative Nanoparticles as Prolonged Releasing Drug Carriers
BT  - Proceedings of the 2016 International Conference on Biological Engineering and Pharmacy (BEP 2016)
PB  - Atlantis Press
SP  - 163
EP  - 168
SN  - 2468-5747
UR  - https://doi.org/10.2991/bep-16.2017.34
DO  - https://doi.org/10.2991/bep-16.2017.34
ID  - FENG2016/12
ER  -