Chitosan Derivative Nanoparticles as Prolonged Releasing Drug Carriers

DOI

10.2991/bep-16.2017.34How to use a DOI?

Keywords

nanocarrier; chitosan derivative; drug carrier

Abstract

Ricinoleic acid grafted amphiphilic carboxymethy chitosan (CMC-g-RA) was synthesized as a carrier to load botanical drug rotenone (Rot). Then Rot/CMC-g-RA water dispersion in nanoscale was prepared, whose shape, zeta potential, loading efficiency and outdoor stability were characterized accordingly. The results indicated that the sizes, polydispersity index, zeta potential of Rot/CMC-g-RA particles were affected by concentrations of this water dispersion. When the ratio of carrier to drug ascended, the water dispersion had monodisperse nanoparticle sizes with negative charge on nanoparticle surface. And the water dispersion restrained Rot degradation in natural environment with higher loading efficiency.

Copyright

© 2017, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Bohua FENG
AU  - Liufen PENG
PY  - 2016/12
DA  - 2016/12
TI  - Chitosan Derivative Nanoparticles as Prolonged Releasing Drug Carriers
BT  - Proceedings of the 2016 International Conference on Biological Engineering and Pharmacy (BEP 2016)
PB  - Atlantis Press
SP  - 163
EP  - 168
SN  - 2468-5747
UR  - https://doi.org/10.2991/bep-16.2017.34
DO  - 10.2991/bep-16.2017.34
ID  - FENG2016/12
ER  -