Chitosan Derivative Nanoparticles as Prolonged Releasing Drug Carriers
- https://doi.org/10.2991/bep-16.2017.34How to use a DOI?
- nanocarrier; chitosan derivative; drug carrier
Ricinoleic acid grafted amphiphilic carboxymethy chitosan (CMC-g-RA) was synthesized as a carrier to load botanical drug rotenone (Rot). Then Rot/CMC-g-RA water dispersion in nanoscale was prepared, whose shape, zeta potential, loading efficiency and outdoor stability were characterized accordingly. The results indicated that the sizes, polydispersity index, zeta potential of Rot/CMC-g-RA particles were affected by concentrations of this water dispersion. When the ratio of carrier to drug ascended, the water dispersion had monodisperse nanoparticle sizes with negative charge on nanoparticle surface. And the water dispersion restrained Rot degradation in natural environment with higher loading efficiency.
- © 2017, the Authors. Published by Atlantis Press.
- Open Access
- This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).
Cite this article
TY - CONF AU - Bohua FENG AU - Liufen PENG PY - 2016/12 DA - 2016/12 TI - Chitosan Derivative Nanoparticles as Prolonged Releasing Drug Carriers BT - Proceedings of the 2016 International Conference on Biological Engineering and Pharmacy (BEP 2016) PB - Atlantis Press SP - 163 EP - 168 SN - 2468-5747 UR - https://doi.org/10.2991/bep-16.2017.34 DO - https://doi.org/10.2991/bep-16.2017.34 ID - FENG2016/12 ER -