Direct activation of Constitutive Androstane Receptor by Phthalates

DOI

10.2991/bep-16.2017.77How to use a DOI?

Keywords

phthalates; constitutive androstane receptor; activation

Abstract

Phthalates are esters of phthalic acid and are mainly used as plasticizers. It was reported that some phthalates activated constitutive androstane receptor (CAR), the major xenobiotic sensor and metabolism regulating nuclear receptor. Here, we compared the effects of CAR activation induced by 15 common used phthalates, and elucidated the species-specific CAR activation by phthalates based on in vitro-in vivo test.

Copyright

© 2017, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Haishan LI
AU  - Guolin SHEN
AU  - Wenchao AI
AU  - Wenping XIE
AU  - Hui HAN
AU  - Huiming CHEN
PY  - 2016/12
DA  - 2016/12
TI  - Direct activation of Constitutive Androstane Receptor by Phthalates
BT  - Proceedings of the 2016 International Conference on Biological Engineering and Pharmacy (BEP 2016)
PB  - Atlantis Press
SP  - 348
EP  - 350
SN  - 2468-5747
UR  - https://doi.org/10.2991/bep-16.2017.77
DO  - 10.2991/bep-16.2017.77
ID  - LI2016/12
ER  -