The Use of Green Coffee and Green Tea Extract as Cost-Effective Herbs to Counteract Obesity by Inhibiting PPAR-γ Gene Expression

Nur Ida Panca Nugrahini; Agustin Krisna Wardani; Mohammad Saifur Rohman; Erryana Martati; Indah Nur Chomsy

doi:10.2991/978-94-6463-140-1_47

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The Use of Green Coffee and Green Tea Extract as Cost-Effective Herbs to Counteract Obesity by Inhibiting PPAR-γ Gene Expression

Authors

Nur Ida Panca Nugrahini¹^{, 2}^{, *}, Agustin Krisna Wardani², Mohammad Saifur Rohman³, Erryana Martati², Indah Nur Chomsy⁴

¹Doctoral Program of Food Science and Biotechnology, Faculty of Agricultural Technology, Universitas Brawijaya, Jalan Veteran, Malang, 65145, Indonesia

²Department of Food Science and Biotechnology, Faculty of Agricultural Technology, Universitas Brawijaya, Jalan Veteran, Malang, 65145, Indonesia

³Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Brawijaya, Jalan Veteran, Malang, 65145, Indonesia

⁴Doctoral Program of Medical Science, Faculty of Medicine, University of Brawijaya, Malang, 65145, Indonesia

^*Corresponding author. Email: idaterbaru@ub.ac.id

Corresponding Author

Nur Ida Panca Nugrahini

Available Online 30 April 2023.

DOI: 10.2991/978-94-6463-140-1_47 How to use a DOI?
Keywords: Green Coffee; Green Tea; PPAR-γ; Intracellular Lipid Accumulation
Abstract: The use of cost-effective herbs in the health sector is an exciting challenge in this era. Supported by environmentally friendly manufacturing processes, green tea and coffee can benefit health, one of which is metabolic syndrome (MetS). MetS therapy using green tea and green coffee, besides having health benefits, also has great potential in the economic sector because coffee is one of the largest sources of export commodities in Indonesia. Green tea and green coffee products as functional drinks are expected to be beneficial for health, one of which is obesity as a major risk factor in MetS. The purpose of this research is to determine the therapeutic effect of green tea and green coffee on molecular markers of obesity: gene expression of PPAR-γ and intracellular lipid accumulation from 3T3-L1 pre-adipocytes. Based on the results of this study, it was found that there was a significant difference between PPAR-γ and all groups (p = 0.00), and lipid accumulation between all groups (p = 0.00). There was a positive correlation between PPAR-γ and intracellular lipid accumulation with a p-value = 0.009 and an R = 0.610. Green tea and green coffee prevent obesity through inhibition of PPARγ gene expression which is characterized by decreased intracellular lipid accumulation in differentiated 3T3-L1 adipocytes.
Open Access: Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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Volume Title: Proceedings of the 2022 Brawijaya International Conference (BIC 2022)
Series: Advances in Economics, Business and Management Research
Publication Date: 30 April 2023
ISBN: 10.2991/978-94-6463-140-1_47
ISSN: 2352-5428
DOI: 10.2991/978-94-6463-140-1_47 How to use a DOI?
Open Access: Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

Cite this article

ris enw bib

TY  - CONF
AU  - Nur Ida Panca Nugrahini
AU  - Agustin Krisna Wardani
AU  - Mohammad Saifur Rohman
AU  - Erryana Martati
AU  - Indah Nur Chomsy
PY  - 2023
DA  - 2023/04/30
TI  - The Use of Green Coffee and Green Tea Extract as Cost-Effective Herbs to Counteract Obesity by Inhibiting PPAR-γ Gene Expression
BT  - Proceedings of the 2022 Brawijaya International Conference (BIC 2022)
PB  - Atlantis Press
SP  - 466
EP  - 476
SN  - 2352-5428
UR  - https://doi.org/10.2991/978-94-6463-140-1_47
DO  - 10.2991/978-94-6463-140-1_47
ID  - Nugrahini2023
ER  -

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