Biofilm Detachment and Its Implication in Spreading Biofilm-Related Infections
- DOI
- 10.2991/978-94-6463-020-6_2How to use a DOI?
- Keywords
- Biofilm; quorum sensing; pathogenicity; dispersion; quorum sensing inhibitor
- Abstract
Biofilms are a community of microorganisms formed on both abiotic and biotic surfaces. These colonies play a vital role in the virulent life cycle of bacteria. Bacteria communicate intrinsically and extrinsically to grow and eventually disperse their virulent factors, ultimately leading to diseases. Biofilm dispersion is the last stage in this life cycle; at this stage, the biofilm has completed maturation. The microorganism then disperses as the biofilm ruptures and assumes a planktonic lifestyle until they find a new surface to attach to and repeat the cycle. This mechanism plays a vital role in the pathogenicity of the microorganism and can be triggered prematurely to disrupt the microorganism's virulent nature. In this mini-review, we have summarized biofilm dispersion, its mechanisms, and the factors influenced by, focusing on their effect on the pathogen's virulence. We have also discussed the significance of quorum sensing and the modern methods used to develop quorum sensing inhibitors through in-silico approaches.
- Copyright
- © 2023 The Author(s)
- Open Access
- Open Access This chapter is licensed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.
Cite this article
TY - CONF AU - Akshat Gupta AU - Anmol Srivastava AU - Vishnu Agarwal PY - 2022 DA - 2022/12/14 TI - Biofilm Detachment and Its Implication in Spreading Biofilm-Related Infections BT - Proceedings of the conference BioSangam 2022: Emerging trends in Biotechnology (BIOSANGAM 2022) PB - Atlantis Press SP - 3 EP - 13 SN - 2468-5747 UR - https://doi.org/10.2991/978-94-6463-020-6_2 DO - 10.2991/978-94-6463-020-6_2 ID - Gupta2022 ER -