Development of the Myricetin Nano-Phytosome Formula with Phosphatidylcholine Variations
- 10.2991/ahsr.k.200523.066How to use a DOI?
- myricetin, nano-phytosome, phosphatidylcholine, thin layer film hydration-sonication
Objectives: Myricetin is a flavonoid compound with natural antioxidant activity. Solubility, permeability and absorption rate is very low makes myricetin’s bioavailability very limited. To address this problem, myricetin made in nano-phytosome technology. Nano-phytosome was made by mixing phytoconstituents and phosphatidylcholine using a specific molar ratio. This study aims to develop the Myricetin Nano-phytosome formula with variations of phosphatidylcholine. Myricetin Nano-phytosome were formulated by making three variations of phosphatidylcholine, the comparisons Myricetin:Phosphatidylcholine:Cholesterol were 1:1:0,4 (F1), 1:2:0,4 (F2), and 1:3:0,4 (F3), using thin layer film hydration-sonication method. Evaluation of nano-phytosome included measurement particle size, absorption efficiency and antioxidant activity. The result showed that particle size of nano-phytosome were F1 (198,1 nm), F2 (276,1 nm), F3 (313,2 nm). Entrapment efficiency F1 (90,28%), F2 (88,82%), F3 (86,91%). The antioxidant activity of Myricetin Nano-phytosome formulas is included as a high antioxidant. Based on the evaluation results, every increasing phosphatidylcholine concentration, the particle size increase and decrease entrapment efficiency.
- © 2020, the Authors. Published by Atlantis Press.
- Open Access
- This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).
Cite this article
TY - CONF AU - Nur Aini Dewi AU - Ganet Eko AU - Muhamad Dzakwan PY - 2020 DA - 2020/06/08 TI - Development of the Myricetin Nano-Phytosome Formula with Phosphatidylcholine Variations BT - The proceedings of the 2nd Bakti Tunas Husada-Health Science International Conference (BTH-HSIC 2019) PB - Atlantis Press SP - 272 EP - 275 SN - 2468-5739 UR - https://doi.org/10.2991/ahsr.k.200523.066 DO - 10.2991/ahsr.k.200523.066 ID - Dewi2020 ER -