The proceedings of the 2nd Bakti Tunas Husada-Health Science International Conference (BTH-HSIC 2019)

Development of the Myricetin Nano-Phytosome Formula with Phosphatidylcholine Variations

Authors
Nur Aini Dewi, Ganet Eko, Muhamad Dzakwan
Corresponding Author
Nur Aini Dewi
Available Online 8 June 2020.
DOI
https://doi.org/10.2991/ahsr.k.200523.066How to use a DOI?
Keywords
myricetin, nano-phytosome, phosphatidylcholine, thin layer film hydration-sonication
Abstract

Objectives: Myricetin is a flavonoid compound with natural antioxidant activity. Solubility, permeability and absorption rate is very low makes myricetin’s bioavailability very limited. To address this problem, myricetin made in nano-phytosome technology. Nano-phytosome was made by mixing phytoconstituents and phosphatidylcholine using a specific molar ratio. This study aims to develop the Myricetin Nano-phytosome formula with variations of phosphatidylcholine. Myricetin Nano-phytosome were formulated by making three variations of phosphatidylcholine, the comparisons Myricetin:Phosphatidylcholine:Cholesterol were 1:1:0,4 (F1), 1:2:0,4 (F2), and 1:3:0,4 (F3), using thin layer film hydration-sonication method. Evaluation of nano-phytosome included measurement particle size, absorption efficiency and antioxidant activity. The result showed that particle size of nano-phytosome were F1 (198,1 nm), F2 (276,1 nm), F3 (313,2 nm). Entrapment efficiency F1 (90,28%), F2 (88,82%), F3 (86,91%). The antioxidant activity of Myricetin Nano-phytosome formulas is included as a high antioxidant. Based on the evaluation results, every increasing phosphatidylcholine concentration, the particle size increase and decrease entrapment efficiency.

Copyright
© 2020, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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Volume Title
The proceedings of the 2nd Bakti Tunas Husada-Health Science International Conference (BTH-HSIC 2019)
Series
Advances in Health Sciences Research
Publication Date
8 June 2020
ISBN
978-94-6252-976-2
ISSN
2468-5739
DOI
https://doi.org/10.2991/ahsr.k.200523.066How to use a DOI?
Copyright
© 2020, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

TY  - CONF
AU  - Nur Aini Dewi
AU  - Ganet Eko
AU  - Muhamad Dzakwan
PY  - 2020
DA  - 2020/06/08
TI  - Development of the Myricetin Nano-Phytosome Formula with Phosphatidylcholine Variations
BT  - The proceedings of the 2nd Bakti Tunas Husada-Health Science International Conference (BTH-HSIC 2019)
PB  - Atlantis Press
SP  - 272
EP  - 275
SN  - 2468-5739
UR  - https://doi.org/10.2991/ahsr.k.200523.066
DO  - https://doi.org/10.2991/ahsr.k.200523.066
ID  - Dewi2020
ER  -