The proceedings of the 2nd Bakti Tunas Husada-Health Science International Conference (BTH-HSIC 2019)

Cocrystallization of Mefenamin Acid and Ascorbic Acid by the Solvent Evaporation Method

Authors
Indra, Physca Fathiyatul Azhariyah, Ratih Aryani
Corresponding Author
Indra
Available Online 8 June 2020.
DOI
https://doi.org/10.2991/ahsr.k.200523.014How to use a DOI?
Keywords
mefenamic acid, ascorbic acid, cocrystallization
Abstract

Objectives: The purpose of this study was to determine the physicochemical properties of mefenamic acid after going through the process cocrystallization using solvent evaporation method and characterization. Method: cocrystallization process is made with 3 ratio (mefenamic acid:ascorbic acid) that is 1:1, 1:2 and 2:1. Physicochemical characteristic of the modified crystal form of aspirin was investigated by polarizing microscopy, X-Ray Powder Diffraction, FT-IR spectrophotometer, Differential Scanning Calorimetry, and thermogravimetric analysis Results and Discussion: Cocrystallization process is made with 3 ratio (mefenamic acid:ascorbic acid) that is 1:1, 1:2 and 2:1. Polarizing microscope analysis showed the same crystal habit with mefenamic acid standard. Analysis melting point by DSC showed 230,3oC (mefenamic acid standard), 229,4oC (1:1), 228,2oC (1:2) and 232,5oC (2:1). The infrared spectrum showed wavelength shift in all samples but not significant. Diffractogram pattern showed new peaks in all samples. Based on the characterization shows that cocrystal formed. The solubility test of the samples 1:1, 1:2 and 2:1 showed increases in solubility compared to mefenamic acid standard. Conclusion: The new crystalline phase has been formed from mefenamic acid and ascorbic acid which has higher solubility than its pure material.

Copyright
© 2020, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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Volume Title
The proceedings of the 2nd Bakti Tunas Husada-Health Science International Conference (BTH-HSIC 2019)
Series
Advances in Health Sciences Research
Publication Date
8 June 2020
ISBN
978-94-6252-976-2
ISSN
2468-5739
DOI
https://doi.org/10.2991/ahsr.k.200523.014How to use a DOI?
Copyright
© 2020, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

TY  - CONF
AU  - Indra
AU  - Physca Fathiyatul Azhariyah
AU  - Ratih Aryani
PY  - 2020
DA  - 2020/06/08
TI  - Cocrystallization of Mefenamin Acid and Ascorbic Acid by the Solvent Evaporation Method
BT  - The proceedings of the 2nd Bakti Tunas Husada-Health Science International Conference (BTH-HSIC 2019)
PB  - Atlantis Press
SP  - 49
EP  - 52
SN  - 2468-5739
UR  - https://doi.org/10.2991/ahsr.k.200523.014
DO  - https://doi.org/10.2991/ahsr.k.200523.014
ID  - 2020
ER  -