Cocrystallization of Mefenamin Acid and Ascorbic Acid by the Solvent Evaporation Method
- 10.2991/ahsr.k.200523.014How to use a DOI?
- mefenamic acid, ascorbic acid, cocrystallization
Objectives: The purpose of this study was to determine the physicochemical properties of mefenamic acid after going through the process cocrystallization using solvent evaporation method and characterization. Method: cocrystallization process is made with 3 ratio (mefenamic acid:ascorbic acid) that is 1:1, 1:2 and 2:1. Physicochemical characteristic of the modified crystal form of aspirin was investigated by polarizing microscopy, X-Ray Powder Diffraction, FT-IR spectrophotometer, Differential Scanning Calorimetry, and thermogravimetric analysis Results and Discussion: Cocrystallization process is made with 3 ratio (mefenamic acid:ascorbic acid) that is 1:1, 1:2 and 2:1. Polarizing microscope analysis showed the same crystal habit with mefenamic acid standard. Analysis melting point by DSC showed 230,3oC (mefenamic acid standard), 229,4oC (1:1), 228,2oC (1:2) and 232,5oC (2:1). The infrared spectrum showed wavelength shift in all samples but not significant. Diffractogram pattern showed new peaks in all samples. Based on the characterization shows that cocrystal formed. The solubility test of the samples 1:1, 1:2 and 2:1 showed increases in solubility compared to mefenamic acid standard. Conclusion: The new crystalline phase has been formed from mefenamic acid and ascorbic acid which has higher solubility than its pure material.
- © 2020, the Authors. Published by Atlantis Press.
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Cite this article
TY - CONF AU - Indra AU - Physca Fathiyatul Azhariyah AU - Ratih Aryani PY - 2020 DA - 2020/06/08 TI - Cocrystallization of Mefenamin Acid and Ascorbic Acid by the Solvent Evaporation Method BT - The proceedings of the 2nd Bakti Tunas Husada-Health Science International Conference (BTH-HSIC 2019) PB - Atlantis Press SP - 49 EP - 52 SN - 2468-5739 UR - https://doi.org/10.2991/ahsr.k.200523.014 DO - 10.2991/ahsr.k.200523.014 ID - 2020 ER -