Evaluation Nano-Phytosome of Myricetin with Thin Layer Film Hydration-Sonication Method
- https://doi.org/10.2991/ahsr.k.200523.070How to use a DOI?
- nano-phytosome, myricetin, thin layer film hydration
Nano-phytosome is a nano technology that’s use to improve the bioavailability of active compound in plants by binding with phospholipids which have similar characteristic with cell membranes. In this study, Myricetin is the main ingredient that we used in nano-phytosome formulation. Myrisetin is a natural flavonoid compound with antioxidant activitiy and has low bioavailability and permeability values. The purpose of this study is to knowing characterization nano-phytosomes of myricetin. Nano-phytosomes is made using thin-sonication hydration method with a variation ratio of myrisetin: phosphatidylcholine: cholesterol 1: 1: 0.4 (F1), 1: 2: 0.4 (F2) and 1: 3: 0.4 (F3). Characterization of nano-phytosome includes particle size, polydispers index, stability, adsorption efficiency and antioxidant activity. The results showed that particle size in F1, F2 and F3 were 233.6 nm, 250.0 nm, and 242.7 nm with polydispersion indexes were 0.260, 0.260 and 0.447, respectively. Potential zeta values (F1) -21.7 mV, (F2) -15.7 mV and (F3) -11.3 mV. Entrapment efficiency (F1) 91.94%, (F2) 91.39% and (F3) 91.39%. The antioxidant activity of the formulas have values (F1) 41,13 ppm; (F2) 25.46 ppm; and (F3) 20.64 ppm. Based on the evaluation results, that the more the concentration of phosphatidylcholine added, the more particle size, polydispersion index, adsorption efficiency and antioxidant activity were increases.
- © 2020, the Authors. Published by Atlantis Press.
- Open Access
- This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).
Cite this article
TY - CONF AU - Yuli Edy Saputra AU - Muhammad Dzakwan AU - Nur Aini Dewi PY - 2020 DA - 2020/06/08 TI - Evaluation Nano-Phytosome of Myricetin with Thin Layer Film Hydration-Sonication Method BT - The proceedings of the 2nd Bakti Tunas Husada-Health Science International Conference (BTH-HSIC 2019) PB - Atlantis Press SP - 294 EP - 297 SN - 2468-5739 UR - https://doi.org/10.2991/ahsr.k.200523.070 DO - https://doi.org/10.2991/ahsr.k.200523.070 ID - Saputra2020 ER -