The proceedings of the 2nd Bakti Tunas Husada-Health Science International Conference (BTH-HSIC 2019)

Evaluation Nano-Phytosome of Myricetin with Thin Layer Film Hydration-Sonication Method

Authors
Yuli Edy Saputra, Muhammad Dzakwan, Nur Aini Dewi
Corresponding Author
Nur Aini Dewi
Available Online 8 June 2020.
DOI
https://doi.org/10.2991/ahsr.k.200523.070How to use a DOI?
Keywords
nano-phytosome, myricetin, thin layer film hydration
Abstract

Nano-phytosome is a nano technology that’s use to improve the bioavailability of active compound in plants by binding with phospholipids which have similar characteristic with cell membranes. In this study, Myricetin is the main ingredient that we used in nano-phytosome formulation. Myrisetin is a natural flavonoid compound with antioxidant activitiy and has low bioavailability and permeability values. The purpose of this study is to knowing characterization nano-phytosomes of myricetin. Nano-phytosomes is made using thin-sonication hydration method with a variation ratio of myrisetin: phosphatidylcholine: cholesterol 1: 1: 0.4 (F1), 1: 2: 0.4 (F2) and 1: 3: 0.4 (F3). Characterization of nano-phytosome includes particle size, polydispers index, stability, adsorption efficiency and antioxidant activity. The results showed that particle size in F1, F2 and F3 were 233.6 nm, 250.0 nm, and 242.7 nm with polydispersion indexes were 0.260, 0.260 and 0.447, respectively. Potential zeta values (F1) -21.7 mV, (F2) -15.7 mV and (F3) -11.3 mV. Entrapment efficiency (F1) 91.94%, (F2) 91.39% and (F3) 91.39%. The antioxidant activity of the formulas have values (F1) 41,13 ppm; (F2) 25.46 ppm; and (F3) 20.64 ppm. Based on the evaluation results, that the more the concentration of phosphatidylcholine added, the more particle size, polydispersion index, adsorption efficiency and antioxidant activity were increases.

Copyright
© 2020, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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Volume Title
The proceedings of the 2nd Bakti Tunas Husada-Health Science International Conference (BTH-HSIC 2019)
Series
Advances in Health Sciences Research
Publication Date
8 June 2020
ISBN
978-94-6252-976-2
ISSN
2468-5739
DOI
https://doi.org/10.2991/ahsr.k.200523.070How to use a DOI?
Copyright
© 2020, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

TY  - CONF
AU  - Yuli Edy Saputra
AU  - Muhammad Dzakwan
AU  - Nur Aini Dewi
PY  - 2020
DA  - 2020/06/08
TI  - Evaluation Nano-Phytosome of Myricetin with Thin Layer Film Hydration-Sonication Method
BT  - The proceedings of the 2nd Bakti Tunas Husada-Health Science International Conference (BTH-HSIC 2019)
PB  - Atlantis Press
SP  - 294
EP  - 297
SN  - 2468-5739
UR  - https://doi.org/10.2991/ahsr.k.200523.070
DO  - https://doi.org/10.2991/ahsr.k.200523.070
ID  - Saputra2020
ER  -