Ethanol Extract Activity of Yellow Pumpkin Flesh (Cucurbita Moschata Duch) on the Cataract Formation

DOI

10.2991/ahsr.k.200523.029How to use a DOI?

Keywords

cataract, Cucurbita moschata Duch, sodium selenit

Abstract

Objectives Oxidative stress is suspected as a major factor triggering cataracts. Yellow pumpkin contains beta-carotene compounds can reducing oxidative stress, and it is suspected to be able to reduce the occurrence of cataracts. This study aims at determining and proving the benefits of yellow pumpkin (Cucurbita moschata Duch) as a deterrent in cataract formation in male albino rats (Wistar strain) induced by Sodium Selenite. Macroscopic and microscopic features of cataract formation on negative controls included in mature cataracts (stadium 3), at the dose I and dose III including incipient cataracts (stadium 2) and dose II including immature cataracts (stadium 1). The average parameter diameter of the lens (μm) of group dose II (1738 ± 583) and dose III (1825 ± 106) experiences a widening of the lens diameter compared to the negative control (1492 ± 52). Whereas, at the dose I (1392 ± 38), there was a narrowing compared to the negative control. The parameters of lens epithelial cell thickness (μm) at dose I (15 ± 3.46), dose II (15.67 ± 5.03), and dose III (9.67 ± 4.62) of ethanol extract of yellow pumpkin showed an increase in thickness lens epithelial cells of mouse compared to negative controls (7 ± 1). The ethanol extract of the flesh of yellow pumpkin showed the improvement of eye health of albino rats (Wistar strain) experienced cataract, although it has not been able to improve it on the whole.

Copyright

© 2020, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Tita Nofianti
AU  - Nurlaili Dwi Hidayati
AU  - Vera Nurviana
AU  - Ruswanto
AU  - L Rani Yunda
PY  - 2020
DA  - 2020/06/08
TI  - Ethanol Extract Activity of Yellow Pumpkin Flesh (Cucurbita Moschata Duch) on the Cataract Formation
BT  - The proceedings of the 2nd Bakti Tunas Husada-Health Science International Conference (BTH-HSIC 2019)
PB  - Atlantis Press
SP  - 118
EP  - 123
SN  - 2468-5739
UR  - https://doi.org/10.2991/ahsr.k.200523.029
DO  - 10.2991/ahsr.k.200523.029
ID  - Nofianti2020
ER  -