Research on the Pros and Cons of the Mouse Model of Alzheimer’s Disease

DOI

10.2991/aebmr.k.220404.056How to use a DOI?

Keywords

Alzheimer’s disease; Mouse model; Generation; Over-expression; Transgenic; Knock-in

Abstract

Alzheimer’s disease (AD) is the biggest cause of dementia, and the animal model has always been a high research priority in treating AD. This paper introduces three generations of AD mouse models by summarizing their merits and limitations in order to facilitate the understanding of these animal models and design more precise experiments in the future. Conclusions can be drawn that the over-expression paradigm of the first generation may cause extra phenotypes which are unrelated to AD, while the second generation overcame this problem but it is still unsuitable to be used in preclinical immunotherapy studies because of the discrete affinity for anti-Aβ antibodies. Finally, the third generation was introduced to the community. Without the Arctic mutation, this generation could also accumulate wild-type human Aβ quickly.

Copyright

© 2022 The Authors. Published by Atlantis Press International B.V.

Open Access

This is an open access article distributed under the CC BY-NC 4.0 license.

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TY  - CONF
AU  - Manke Cai
PY  - 2022
DA  - 2022/04/18
TI  - Research on the Pros and Cons of the Mouse Model of Alzheimer’s Disease
BT  - Proceedings of the 2022 International Conference on Creative Industry and Knowledge Economy (CIKE 2022)
PB  - Atlantis Press
SP  - 300
EP  - 304
SN  - 2352-5428
UR  - https://doi.org/10.2991/aebmr.k.220404.056
DO  - 10.2991/aebmr.k.220404.056
ID  - Cai2022
ER  -