Investigating the Relationship Between Aging and Epigenetic Differences in Monozygotic Twins

DOI

10.2991/aebmr.k.220404.069How to use a DOI?

Keywords

Epigenetics; Monozygotic Twins; DNA Methylation; Histone Acetylation

Abstract

When it comes to monozygotic twins, Mario F. Fraga and colleagues’ paper “Epigenetic differences arise during the lifetime of monozygotic twins” focuses on epigenetic modifications in monozygotic twins and what causes monozygotic twins to become more distinct as they age. This study is going to compare epigenetic profiles of monozygotic twin siblings of varying ages and genders. This includes DNA methylation as well as histone acetylation patterns in the H3 and H4 histone regions. Even though monozygotic twins were difficult to distinguish in their early lives, it has been observed that the older twins have shown significant differences in histone acetylation and the genomic distribution of some DNAs, which affects their gene expression and, as a result, makes them appear more distinct. One of the most common causes of monozygotic twin discordance is the presence of a specific disease in only one of the twins. As a result, understanding the role that epigenetic factors play in the development of monozygotic twins is critical because it allows us to identify diseases that can be prevented or treated.

Copyright

© 2022 The Authors. Published by Atlantis Press International B.V.

Open Access

This is an open access article distributed under the CC BY-NC 4.0 license.

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TY  - CONF
AU  - Wynnie Feng
PY  - 2022
DA  - 2022/04/18
TI  - Investigating the Relationship Between Aging and Epigenetic Differences in Monozygotic Twins
BT  - Proceedings of the 2022 International Conference on Creative Industry and Knowledge Economy (CIKE 2022)
PB  - Atlantis Press
SP  - 368
EP  - 371
SN  - 2352-5428
UR  - https://doi.org/10.2991/aebmr.k.220404.069
DO  - 10.2991/aebmr.k.220404.069
ID  - Feng2022
ER  -