PEG-Coated Titania Nanatubes for Controlled Drug Release

DOI

10.2991/cmfe-15.2015.27How to use a DOI?

Keywords

Titania nanotube; PEG; hydrothermal method; ibuprofen; Drug Release

Abstract

Developing coatings on implant surface as drug carriers can reduce organ toxicity and effectively deliver drug locally to the target compared with the oral approach. Titanium dioxide (TiO2) nanotube has great potential for this application for widely used Ti implants because of its high surface area, ability to promote bone growth, and biocompatibility. However,there are two issues needed to be solved before further advancing TiO2 nanotubes technology as drug carriers: uncontrolled drug release and poor mechanical properties. PEG by hydrothermal method will load onto titania nanotube arrays coating over the drug-loaded titania nanotube arrays to improve the properties of drug release. The samples were characterized by scanning electronic microscope (SEM). The results show that TNTs modified by PEG-coated possess improved drug release characteristics with reduced burst release (from 89% to 69%) and prolonged drug release (from 9 days to over 15 days). This approach provides an alternative to tailor the surface of TNTs and offer considerable prospects for diverse biomedical applications.

Copyright

© 2015, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Fei Luo
AU  - Guojie Xu
AU  - Yan Liu
AU  - Chunling Xie
AU  - Xiufeng Xiao
PY  - 2015/07
DA  - 2015/07
TI  - PEG-Coated Titania Nanatubes for Controlled Drug Release
BT  - Proceedings of the International Conference on Chemical, Material and Food Engineering
PB  - Atlantis Press
SP  - 110
EP  - 113
SN  - 2352-5401
UR  - https://doi.org/10.2991/cmfe-15.2015.27
DO  - 10.2991/cmfe-15.2015.27
ID  - Luo2015/07
ER  -