Study of Nano Hydroxyapatite/ Poly(Lactic Acid)-Polycaprolactone Nanofiber Composite Scaffolds

DOI

10.2991/cmfe-15.2015.67How to use a DOI?

Keywords

hydroxyapatite composite scaffold; nanofibers; thermal induced phase separation technique; in-situ precipitation; frozen extraction

Abstract

At present, tissue engineering scaffolds in the process of clinical medicine plays an irreplaceable important role. Based on the in-situ precipitation combined with frozen extraction, good n-HA dispersion and three-dimensional (3D) structure of n-HA/PLLA-PCL composite nanofibrous scaffolds were prepared. The effects of the proportion of polymer, gel temperature and the amount of calcium phosphate solution on the morphology of nanofibrous scaffolds were investigated. From the experimental results,it can be concluded that the scaffolds’ morphology have changed while the proportions of the polymer are different, and with more PCL, the fiber diameter increases. At low gel temperature (-10°C or lower), n-HA/PLLA-PCL composite scaffolds could be able to get relatively uniform nano fiber network structure, while at high gel temperature (0°C or higher), nanofibers tend to flake growth, support structure is more compact. Also, with the adding of (NH4)2HPO4 solution, nanometer fiber diameter increases, however, the degree of uniformity decreases.

Copyright

© 2015, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Guojie Xu
AU  - Fei Luo
AU  - Yan Liu
AU  - Shunyu Chen
AU  - Xiufeng Xiao
PY  - 2015/07
DA  - 2015/07
TI  - Study of Nano Hydroxyapatite/ Poly(Lactic Acid)-Polycaprolactone Nanofiber Composite Scaffolds
BT  - Proceedings of the International Conference on Chemical, Material and Food Engineering
PB  - Atlantis Press
SP  - 281
EP  - 284
SN  - 2352-5401
UR  - https://doi.org/10.2991/cmfe-15.2015.67
DO  - 10.2991/cmfe-15.2015.67
ID  - Xu2015/07
ER  -