Proceedings of the 2016 7th International Conference on Education, Management, Computer and Medicine (EMCM 2016)

Synthesis of Cinnamic Acid Derivatives

Authors
Lei Zhao, Yuanbiao Tu, Yuping Guo
Corresponding Author
Lei Zhao
Available Online February 2017.
DOI
https://doi.org/10.2991/emcm-16.2017.85How to use a DOI?
Keywords
Cinnamic derivatives, Synthesis, Optimization
Abstract
Quinazoline derivatives have been shown to be biologically active such as afatinib. The cinnamic acid derivative is an important part of the quinazoline derivative which exerts its activity. And Cinnamic acid derivatives were prepared by the benzaldehyde derivatives and malonic acids. In this paper, four cinnamic acid derivatives were prepared. The structure was confirmed by MS and 1H NMR. In addition, this method not only saved the reaction time, but also improved the purity of the product. The yield of the step was about 90%.
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Proceedings
2016 7th International Conference on Education, Management, Computer and Medicine (EMCM 2016)
Part of series
Advances in Computer Science Research
Publication Date
February 2017
ISBN
978-94-6252-297-8
ISSN
2352-538X
DOI
https://doi.org/10.2991/emcm-16.2017.85How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - CONF
AU  - Lei Zhao
AU  - Yuanbiao Tu
AU  - Yuping Guo
PY  - 2017/02
DA  - 2017/02
TI  - Synthesis of Cinnamic Acid Derivatives
BT  - 2016 7th International Conference on Education, Management, Computer and Medicine (EMCM 2016)
PB  - Atlantis Press
SN  - 2352-538X
UR  - https://doi.org/10.2991/emcm-16.2017.85
DO  - https://doi.org/10.2991/emcm-16.2017.85
ID  - Zhao2017/02
ER  -