Proceedings of the 2016 7th International Conference on Education, Management, Computer and Medicine (EMCM 2016)

Synthesis of 4-chloro-6-methoxy-2-methyl-3-nitroquinoline

Authors
Lei Zhao, Fei Lei, Yuping Guo
Corresponding Author
Lei Zhao
Available Online February 2017.
DOI
https://doi.org/10.2991/emcm-16.2017.104How to use a DOI?
Keywords
4-Chloro-6-methoxy-2-methyl-3-nitroquinoline; PI3K/mTOR inhibitor; Synthesis
Abstract
4-Chloro-6-methoxy-2-methyl-3-nitroquinoline (1) was synthesized from 4-methoxyaniline through three steps including Cyclization, Nitrification and Chlorination. The structure of the target product (1) was confirmed by 1H NMR and MS. This method started with cheap raw materials was of simple experimental operation and mild reaction conditions. It was suitable for large scale pilot study and the yield of the product is achieved to 85%.
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Proceedings
2016 7th International Conference on Education, Management, Computer and Medicine (EMCM 2016)
Part of series
Advances in Computer Science Research
Publication Date
February 2017
ISBN
978-94-6252-297-8
ISSN
2352-538X
DOI
https://doi.org/10.2991/emcm-16.2017.104How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - CONF
AU  - Lei Zhao
AU  - Fei Lei
AU  - Yuping Guo
PY  - 2017/02
DA  - 2017/02
TI  - Synthesis of 4-chloro-6-methoxy-2-methyl-3-nitroquinoline
BT  - 2016 7th International Conference on Education, Management, Computer and Medicine (EMCM 2016)
PB  - Atlantis Press
SN  - 2352-538X
UR  - https://doi.org/10.2991/emcm-16.2017.104
DO  - https://doi.org/10.2991/emcm-16.2017.104
ID  - Zhao2017/02
ER  -