Synthesis of 4-chloro-6-methoxy-2-methyl-3-nitroquinoline
Lei Zhao, Fei Lei, Yuping Guo
Available Online February 2017.
- https://doi.org/10.2991/emcm-16.2017.104How to use a DOI?
- 4-Chloro-6-methoxy-2-methyl-3-nitroquinoline; PI3K/mTOR inhibitor; Synthesis
- 4-Chloro-6-methoxy-2-methyl-3-nitroquinoline (1) was synthesized from 4-methoxyaniline through three steps including Cyclization, Nitrification and Chlorination. The structure of the target product (1) was confirmed by 1H NMR and MS. This method started with cheap raw materials was of simple experimental operation and mild reaction conditions. It was suitable for large scale pilot study and the yield of the product is achieved to 85%.
- Open Access
- This is an open access article distributed under the CC BY-NC license.
Cite this article
TY - CONF AU - Lei Zhao AU - Fei Lei AU - Yuping Guo PY - 2017/02 DA - 2017/02 TI - Synthesis of 4-chloro-6-methoxy-2-methyl-3-nitroquinoline BT - 2016 7th International Conference on Education, Management, Computer and Medicine (EMCM 2016) PB - Atlantis Press SN - 2352-538X UR - https://doi.org/10.2991/emcm-16.2017.104 DO - https://doi.org/10.2991/emcm-16.2017.104 ID - Zhao2017/02 ER -