Synthesis of 2 - ((4-Substituted Phenyl) Amino) Benzaldehyde
Yongli Duan, Zhimin Li, Qidong Tang, Rui Li, Shan Xu
Available Online February 2017.
- https://doi.org/10.2991/emcm-16.2017.109How to use a DOI?
- 2-((4-substituted phenyl) amino) benzaldehyde; Synthesis; Process optimization
- 2-((4-substituted phenyl) amino) benzaldehyde, is an important intermediate for the synthesis of many biologically active intermediates of anticancer drugs. In this work, a rapid and high efficiency synthetic method for compound 1a-1b was established. Compound 1a-1b was synthesized from 2-chloronicotinic acid and 4-substituted anilines through three steps including nucleophilic substitution, reduction and oxidation reaction. The structure of the target compound 1a-1b was confirmed by H NMR and MS spectrum. Furthermore, the synthetic method was optimized. The total yield of the three steps was 59.49%.
- Open Access
- This is an open access article distributed under the CC BY-NC license.
Cite this article
TY - CONF AU - Yongli Duan AU - Zhimin Li AU - Qidong Tang AU - Rui Li AU - Shan Xu PY - 2017/02 DA - 2017/02 TI - Synthesis of 2 - ((4-Substituted Phenyl) Amino) Benzaldehyde BT - 2016 7th International Conference on Education, Management, Computer and Medicine (EMCM 2016) PB - Atlantis Press SN - 2352-538X UR - https://doi.org/10.2991/emcm-16.2017.109 DO - https://doi.org/10.2991/emcm-16.2017.109 ID - Duan2017/02 ER -