Synthesis of 1-(2-(piperidin-1-yl)ethyl)-1H-pyrrole-2-carbaldehyde
Caolin Wang, Yuanbiao Tu, Jiaqian Han, Yuping Guo
Available Online February 2017.
- https://doi.org/10.2991/emcm-16.2017.114How to use a DOI?
- 1H-pyrrole-2-carbaldehyde; Synthesis
- 1-(2-(piperidin-1-yl)ethyl)-1H-pyrrole-2-carbaldehyde 4a-b is a new aqueous solubility aldehyde as an important intermediates of small molecule anticancer drugs. In this work, a rapid synthetic method for target compounds 4a-b was established. The compound 4a-b was synthesized from the commercially available pyrrole through three steps including acylation and two steps nucleophilic substitution. The structure was confirmed by MS and 1HNMR. Furthermore, the synthetic method was optimized. The total yield of the three steps was 65%
- Open Access
- This is an open access article distributed under the CC BY-NC license.
Cite this article
TY - CONF AU - Caolin Wang AU - Yuanbiao Tu AU - Jiaqian Han AU - Yuping Guo PY - 2017/02 DA - 2017/02 TI - Synthesis of 1-(2-(piperidin-1-yl)ethyl)-1H-pyrrole-2-carbaldehyde BT - 2016 7th International Conference on Education, Management, Computer and Medicine (EMCM 2016) PB - Atlantis Press SN - 2352-538X UR - https://doi.org/10.2991/emcm-16.2017.114 DO - https://doi.org/10.2991/emcm-16.2017.114 ID - Wang2017/02 ER -