Proceedings of the 2016 7th International Conference on Education, Management, Computer and Medicine (EMCM 2016)

Synthesis of 1-(2-(piperidin-1-yl)ethyl)-1H-pyrrole-2-carbaldehyde

Authors
Caolin Wang, Yuanbiao Tu, Jiaqian Han, Yuping Guo
Corresponding Author
Caolin Wang
Available Online February 2017.
DOI
https://doi.org/10.2991/emcm-16.2017.114How to use a DOI?
Keywords
1H-pyrrole-2-carbaldehyde; Synthesis
Abstract
1-(2-(piperidin-1-yl)ethyl)-1H-pyrrole-2-carbaldehyde 4a-b is a new aqueous solubility aldehyde as an important intermediates of small molecule anticancer drugs. In this work, a rapid synthetic method for target compounds 4a-b was established. The compound 4a-b was synthesized from the commercially available pyrrole through three steps including acylation and two steps nucleophilic substitution. The structure was confirmed by MS and 1HNMR. Furthermore, the synthetic method was optimized. The total yield of the three steps was 65%
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Proceedings
2016 7th International Conference on Education, Management, Computer and Medicine (EMCM 2016)
Part of series
Advances in Computer Science Research
Publication Date
February 2017
ISBN
978-94-6252-297-8
ISSN
2352-538X
DOI
https://doi.org/10.2991/emcm-16.2017.114How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - CONF
AU  - Caolin Wang
AU  - Yuanbiao Tu
AU  - Jiaqian Han
AU  - Yuping Guo
PY  - 2017/02
DA  - 2017/02
TI  - Synthesis of 1-(2-(piperidin-1-yl)ethyl)-1H-pyrrole-2-carbaldehyde
BT  - 2016 7th International Conference on Education, Management, Computer and Medicine (EMCM 2016)
PB  - Atlantis Press
SN  - 2352-538X
UR  - https://doi.org/10.2991/emcm-16.2017.114
DO  - https://doi.org/10.2991/emcm-16.2017.114
ID  - Wang2017/02
ER  -