Analysis on Separation and Purification of Corosolic Acid and Antitumor Activity

DOI

10.2991/emcpe-16.2016.32How to use a DOI?

Keywords

Loquat Leaf, Corosolic Acid, Separation and Purification, MTT Method

Abstract

Objective: To make a study of the separation and purification of purified corosolic acid from loquat leaf extract using the traditional Chinese medicine technology and the separation process in different samples of human gastric carcinoma BGC823 cell growth inhibition. Methods: 95% ethanol extracts were purified by macroporous adsorption resin, silica gel column chromatography and preparative chromatography. The MTT method was used to test the effects of different samples on the growth of BGC823 in gastric cancer cells. Results: corosolic acid can inhibit the growth of gastric cancer cell line BGC823, isolated from different Coro cable acid samples with different degree of inhibition and other components (such as hawthorn acid or mature acid) and the coronation cable acid can produce synergistic effect. Conclusion: the method can provide experimental basis for the establishment of purification of corosolic acid and the development of new anticancer drugs.

Copyright

© 2016, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Shucai Liang
PY  - 2016/08
DA  - 2016/08
TI  - Analysis on Separation and Purification of Corosolic Acid and Antitumor Activity
BT  - Proceedings of the 2016 5th International Conference on Environment, Materials, Chemistry and Power Electronics
PB  - Atlantis Press
SP  - 151
EP  - 154
SN  - 2352-5401
UR  - https://doi.org/10.2991/emcpe-16.2016.32
DO  - 10.2991/emcpe-16.2016.32
ID  - Liang2016/08
ER  -