Constructed amphiphilic gel as natural auxiliary medium to mimick remineralized dental hydroxyapatite

DOI

10.2991/emcpe-16.2016.155How to use a DOI?

Keywords

Hydroxyapatite, N-methylene phosphonic chitosan, reconstruction

Abstract

For obtain enamel-like hydroxyapatite, we are trying to induce the growth of crystal with modified chitosan which can simulate the organic template like extracellular matrix--Amelogenin to induce the deposition of miner ions. Phosphorous acid modification was applying into natural polycation polysaccharide chitosan to synthesize polyanion derivate phosphorylated chitosan. Amphiphilic hydrogels combined with phosphorylated chitosan (+cation) and gelatin (-anion) were built through peptide binding reaction which using Genipin as crosslinker. The gels self assembled on the inert surface of tooth which stimulated by ultraviolet radiation. CaCl2 and Na3PO4-12H2O solutions provided mineralized ion then the hydroxyapatite assembled and grown in situ of the tooth. All of the samples detected by FTIR, SEM and XRD to confirm the character of neonatal crystal. The amphiphilic gel can enhance the proportion of organic elements on the surface of dentin which confirmed by FTIR. After mineralized reaction, we observed bunch and column (15-25nm) crystal arranged on the dentin base. XRD result showed the neonatal crystal is hydroxyapatite and scratch tester testified the coalescent force between 22-25N. The amphiphilic gel can be induced the enamel-like crystal grown under demineralizing tooth basement.

Copyright

© 2016, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Kun Tian
AU  - Yuanyuan Liu
AU  - Xiaoyun Feng
AU  - Xiaohua Ren
AU  - ChuHang Liao
AU  - Qin Du
PY  - 2016/08
DA  - 2016/08
TI  - Constructed amphiphilic gel as natural auxiliary medium to mimick remineralized dental hydroxyapatite
BT  - Proceedings of the 2016 5th International Conference on Environment, Materials, Chemistry and Power Electronics
PB  - Atlantis Press
SP  - 601
EP  - 607
SN  - 2352-5401
UR  - https://doi.org/10.2991/emcpe-16.2016.155
DO  - 10.2991/emcpe-16.2016.155
ID  - Tian2016/08
ER  -