The Lipase-catalyzed Synthesis of Ethyl Ferulate
Qiannan Wang, Wei Zhang, Jiaying Xin
Available Online April 2016.
- https://doi.org/10.2991/emim-16.2016.351How to use a DOI?
- Lipase; Ethyl ferulate; Biocatalytic synthesis; Ferulic acid
- Selective biocatalytic synthesis is an important part of the third generation of biotechnology, is the forefront of international scientific and technological development. Utilizing enzyme catalyzed reaction, many complex substances can be synthesized. Biocatalysis have strict regional selectivity and enantioselectivity. Ferulic acid is naturally safe radical quencher and anti-oxidation agent. In the cosmetics industry, ferulic acid is considered to be the best natural sunscreen, also used as skin whitening agents. Ferulic acid and its derivatives are widely used in the pharmaceutical industry, the application in the food industry are also increasing. This paper studied the immobilized lipase-catalyzed synthesis of ethyl ferulate in organic medium. Lipase from Mucor sp.M-2 was immobilized with diatomite powder as the carrier by absorption and was used as biocatalyst. The reaction medium were compared for biocatalytic synthesis of ethyl ferulate. The optimum solvent is tert-butyl alcohol .The opitimization of reaction conditions was obtained. In the 4ml of tert butyl alcohol, when the molar ratio of acid to alcohol is 1.5:1 ,the temperature is 45 degrees centigrade, a yield of 9.9% for ethyl ferulate can be obtained after 120h.
- Open Access
- This is an open access article distributed under the CC BY-NC license.
Cite this article
TY - CONF AU - Qiannan Wang AU - Wei Zhang AU - Jiaying Xin PY - 2016/04 DA - 2016/04 TI - The Lipase-catalyzed Synthesis of Ethyl Ferulate BT - 6th International Conference on Electronic, Mechanical, Information and Management Society PB - Atlantis Press SP - 1728 EP - 1732 SN - 2352-538X UR - https://doi.org/10.2991/emim-16.2016.351 DO - https://doi.org/10.2991/emim-16.2016.351 ID - Wang2016/04 ER -