Neurosteroids and their neuroprotective actions

DOI

10.2991/hsic-17.2017.35How to use a DOI?

Keywords

Neurosteroids, Neurodegeneration, Neuroprotection

Abstract

From biochemical point of view neurosteroids are steroid hormone derivatives that devoid hormonal action but affect neuronal excitability through ionotropic receptors. Neurosteroids are further subdivided into natural (produced in the brain) and synthetic. Nevertheless, some authors subdivide also natural neurosteroids into hormonal and regular (non-hormonal) ones, for example two hormone metabolites (allopregnanolone and tetrahydrodeoxycorticosterone) that devoid of hormonal activity. Hormonal neurosteroids may present neuroprotective effects realized in both genomic and non-genomic mechanisms. In details, they involve regulation of the pro- and anti-apoptotic factors expression, intracellular signaling pathways, neurotransmission, oxidative, and inflammatory processes. Since regular neurosteroids show no affinity for steroid receptors, they may act only in a non-genomic mode. Conclusion: Many efforts have been done to show efficacy of neurosteroids in the treatment of the central and peripheral nervous system injury, ischemia, neurodegenerative diseases, or seizures. However, knowledge about neuroactive steroids remains incomplete and still requires confirmation in clinical conditions

Copyright

© 2017, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

Download article (PDF)

TY  - CONF
AU  - Kinga Borowicz-Reutt
PY  - 2017/10
DA  - 2017/10
TI  - Neurosteroids and their neuroprotective actions
BT  - Proceedings of the Health Science International Conference (HSIC 2017)
PB  - Atlantis Press
SP  - 216
EP  - 226
SN  - 2468-5739
UR  - https://doi.org/10.2991/hsic-17.2017.35
DO  - 10.2991/hsic-17.2017.35
ID  - Borowicz-Reutt2017/10
ER  -