Black Cummin Extract (Nigella sativa Linn) on Spatial Memory Performance in Menopausal Model of Rat
- 10.2991/hsic-17.2017.40How to use a DOI?
- Nigella Sativa Extract; Menopausal Model Of Rat; Spatial Memory Performance
The loss of the ability for learning and memorizing is a prominent feature of dementia, which affects millions of menopausal women all over the world. Nigella sativa is a herbal medicine known to have estrogenic, antioxidant and neuroprotective effects thought to improve memory function in dementia. Objective : This present study investigated the effect of Nigella sativa extract (NS) administration on the spatial memory performance (SMP) of menopausal model of rat. Methods : Experimental with post test only control group design. Bilateral ovariectomy (OVX) was performed in all rats. Two weeks post OVX, the rat has a hypoestrogen condition. There were 6 experimental groups namely OVX group as control and 5 groups of OVX rats treated with NS (OVX +NS) with each dose of 1,25; 2,5; 5; 10 and 20 mg/kgBB. NS were administered after 2 weeks post OVX by intragastric gavage daily for 4 weeks. After NS administered, SMP was evaluated of each rat for 6 consecutive days using Water Morris Maze (WMZ). The time latency to reach the hidden platform was recorded. Result : On the sixth day of practice, the mean of time latency to reach the hidden platform by OVX+NS group with dose 1,25; 2,5 and 5 mg/kgBB were shorter than control group but not significant (P>0.05), while OVX+NS group in dose 10 and 20mg/kg were longer than control group (P>0.05). Conclusion : NS extract could not increased the SMP of OVX rats. Probably because NS is more effective to use since pre-menopause
- © 2017, the Authors. Published by Atlantis Press.
- Open Access
- This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).
Cite this article
TY - CONF AU - Fathiyah Safithri AU - Kusuma Andriani PY - 2017/10 DA - 2017/10 TI - Black Cummin Extract (Nigella sativa Linn) on Spatial Memory Performance in Menopausal Model of Rat BT - Proceedings of the Health Science International Conference (HSIC 2017) PB - Atlantis Press SP - 254 EP - 263 SN - 2468-5739 UR - https://doi.org/10.2991/hsic-17.2017.40 DO - 10.2991/hsic-17.2017.40 ID - Safithri2017/10 ER -