The Role of Probiotics in Inflammatory Responses of Critically-Ill Burn Patients (A Randomized Clinical Trial)

DOI

10.2991/hsic-17.2017.61How to use a DOI?

Keywords

Probiotics, Burn Patients, Leucocyte, Neutrophil

Abstract

Impairment of intestinal barrier function and increased translocation of bacteria to the systemic blood flow contribute to the emergence of sepsis in burn patients. Oral probiotic administration has been advocated for treatment dan prevention of diverse range of infection disease by modulating the host immune reponse. Objectives: This research was to determine the effect of mono and multistrain probiotics containing Lactobacillus, Bifidobacterium and Streptococcus thermophilus on leucocyte dan neutrophil level and on the outcome in burn patients. Methods: Twenty-three burn patients with burns involving more than 15% total body surface area were randomized in a prospective, double-blind, non-placebo clinical trial assigned to receive mono and multistrain probiotics (Lactobaccilus and Bifidobacteria) once daily for consecutive fourteen days. Laboratory measurements of Leucocyte and Neutrophil were done on days 4 dan 19. Clinical outcomes including incidence of diarrhea, infection, and mortality were also recorded. Results: There was no incidence of diarrhea and incidence of sepsis and also mortality were similiar between two groups during this study. Multistrain probiotics reduced significant level both of leucocytes and neutrophil during this study (P < 0,05) with significant differences between two groups only in neutrophil level. Conclusion: Administration of monostrain and multistrain probiotics to burn patients caused better clinical outcomes and reduced level of inflammatory parameters (leucocyte and neutrophil). It might be considered as an adjunctive therapy in the treatment of burn patients to treat infection.

Copyright

© 2017, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

Download article (PDF)

TY  - CONF
AU  - Oki Putra
AU  - Hengky Pebrianton
AU  - Suharjono Suharjono
AU  - Iswinarno Iswinarno
AU  - Dwi Rahayu
PY  - 2017/10
DA  - 2017/10
TI  - The Role of Probiotics in Inflammatory Responses of Critically-Ill Burn Patients (A Randomized Clinical Trial)
BT  - Proceedings of the Health Science International Conference (HSIC 2017)
PB  - Atlantis Press
SP  - 390
EP  - 398
SN  - 2468-5739
UR  - https://doi.org/10.2991/hsic-17.2017.61
DO  - 10.2991/hsic-17.2017.61
ID  - Putra2017/10
ER  -