DL-Tetrahydropalmatine Inhibits Heroin Self-Administration in Rats

DOI

10.2991/aer.k.210817.007How to use a DOI?

Keywords

DL-THP, Heroin, Dopamine receptor, Self-administration

Abstract

DL-Tetrahydropalmatine is a Chinese herbal medicine used for analgesic purposes, whose main active compounds isolated from Corydalis. We investigate the effects of male Sprague-Dawley rats on heroin self-administration(SA) to examine the role for DL-THP. Rats were trained to intravenous injection heroin by self-administration for 12 consecutive days, then received DL-THP (5.0-20.0 mg/kg) on day 13. Our results showed that DL-THP (5.0 and 10.0 mg/kg) attenuated heroin self-administration without affect locomotion. The result showed that DL-THP inhibits heroin reinforcement.

Copyright

© 2021, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Ma BaoMiao
AU  - Yue Kai
AU  - Pi mingshan
AU  - Tian Xiang
AU  - Xiong Qi
PY  - 2021
DA  - 2021/08/18
TI  - DL-Tetrahydropalmatine Inhibits Heroin Self-Administration in Rats
BT  - Proceedings of the 2021 10th International Conference on Applied Science, Engineering and Technology (ICASET 2021)
PB  - Atlantis Press
SP  - 33
EP  - 35
SN  - 2352-5401
UR  - https://doi.org/10.2991/aer.k.210817.007
DO  - 10.2991/aer.k.210817.007
ID  - BaoMiao2021
ER  -