Proceedings of the 4th International Conference Current Breakthrough in Pharmacy (ICB-Pharma 2022)

Pharmacological Activity of Mangrove Plant Bioactive Compounds Against Cancer Cell Changes: A Systematic Review

Authors
Dwi Bagus Pambudi1, *, Haryoto1
1Faculty of Pharmacy, Universitas Muhammadiyah Surakarta, Jl. A. Yani, Tromol Pos I, Pabelan, Kartasura, Sukoharjo, 57162, Indonesia
*Corresponding author. Email: dwibagus589@gmail.com
Corresponding Author
Dwi Bagus Pambudi
Available Online 14 December 2022.
DOI
10.2991/978-94-6463-050-3_24How to use a DOI?
Keywords
Mangrove; Bioactive Compound; Cancer Cells
Abstract

Cancer is a condition when the body's cells begin to grow abnormally and uncontrollably. Cancer therapy which is often used in medicine is non-selective, it can affect other normal cells that have a toxic effect in addition beside the activity as anticancer, to overcome this herbal plants have potential as anticancer one of them is mangroves. The research method uses a systematic review of the Science Direct, Pubmed, and Google Scholar databases that meet the inclusion and exclusion criteria. The results of the analysis show that the cytotoxic potential of cancer cells can be done by calculating the percentage of living cells with an IC50 value, which is a concentration that can kill half of cancer cells. The content of bioactive compounds from mangrove plant extracts include taurine, apigenin, lupeol, quercetin, alkaline benzoquinone, polyprenol and dolichol which have antioxidant and anticancer activity. These compounds work as mitogenic agents, namely inflammatory activation, cell mobility, angiogenesis, inhibition of protein kinases, antiproliferation, induction of apoptosis, and inhibition of metastasis.

Copyright
© 2023 The Author(s)
Open Access
Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

Download article (PDF)

Volume Title
Proceedings of the 4th International Conference Current Breakthrough in Pharmacy (ICB-Pharma 2022)
Series
Atlantis Highlights in Chemistry and Pharmaceutical Sciences
Publication Date
14 December 2022
ISBN
10.2991/978-94-6463-050-3_24
ISSN
2590-3195
DOI
10.2991/978-94-6463-050-3_24How to use a DOI?
Copyright
© 2023 The Author(s)
Open Access
Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

Cite this article

TY  - CONF
AU  - Dwi Bagus Pambudi
AU  - Haryoto
PY  - 2022
DA  - 2022/12/14
TI  - Pharmacological Activity of Mangrove Plant Bioactive Compounds Against Cancer Cell Changes: A Systematic Review
BT  - Proceedings of the 4th International Conference Current Breakthrough in Pharmacy (ICB-Pharma 2022)
PB  - Atlantis Press
SP  - 283
EP  - 292
SN  - 2590-3195
UR  - https://doi.org/10.2991/978-94-6463-050-3_24
DO  - 10.2991/978-94-6463-050-3_24
ID  - Pambudi2022
ER  -