Proceedings of the 4th International Conference Current Breakthrough in Pharmacy (ICB-Pharma 2022)
Arifah Sri Wahyuni, Lilla Prapdhani Agni Hajma, Refsya Azanti Putri
All of the articles in this proceedings volume have been presented at the 4th ICCBP 2022 (International Conference of Current Breakthrough in Pharmacy 2022 during 14–15 January 2022 in Surakarta Indonesia. These articles have been peer reviewed by the members of the Scientific Committee and approved...
Release Profile of Betanin from Chitosan Microparticle Containing Beetroot (Beta vulgaris Linn) Extract
Anita Sukmawati, Isna V. Risdiyanti, Clara C. Marthadilla
Beetroot (Beta vulgaris L.) was formulated into Microparticles (MP) to maintain its antioxidant stability and control the release of active substances for longer use. Chitosan was used as a matrix to encapsulate beetroot extract. This study aims to determine the effect of chitosan concentration on drug...
Erindyah Retno Wikantyasning, Hasna Adilia Wibowo
Virus infections are one of the leading causes of rising global health threats. Increasing virus infections will encourage the development of faster and more accurate diagnostic methods. Gold nanoparticle biosensors have the potential to become a simple and rapid colorimetric-based diagnostic method....
SNEDDS Formulation for the Combination of Snakehead Fish (Channa striata) and Bitter Melon (Momordica charantia L.) Extract
Wa Ode Indah Wulan Hartini Halir, Muhtadi, Erindyah Retno Wikantyasning
The combination of Snakehead Fish Powder (SFP) and Bitter Melon Extract (BME) was possible to lower blood sugar levels and antidiabetic agents. The combination of SFP and BME through the mechanism of Self-Nanoemulsifying Drug Delivery Systems (SNEDDS) was carried out. The SNEDDS are forms of lipid-based...
The Potential Effect of Conferment Jamu “Pegal Linu” to Pharmacokinetics of Paracetamol in Wistar Male Rats (Rattus norvegicus L.)
Gilang R. Farizi, Ovikariani, Rahmasani, Any M. Sari, L. Isti’adzah
Paracetamol (acetaminophen) is a ubiquitous drug usually prescribed for its analgesic and antipyretic effects. It is a readily available over-the-counter medication. Consumption of jamu and paracetamol causes pharmacokinetic interaction. This study aimed to determine how much the potential of jamu “pegal...
Yupaporn Preechagoon, Samaporn Kawboot, Supabhorn Onsanit
The main class of drugs specific treatment for pulmonary arterial hypertension (PAH) were calcium channel blocker, sildenafil, bosentan, beraprost and iloprost. Bosentan is a competitive, specific dual receptor (ET-A and ET-B) antagonist. The aim of this study was to investigate the pattern, reason,...
Fadillah Ayu Sekar Waras Pratiknya, Fita Rahmawati
Adverse drug reactions can increase morbidity and mortality in hospitals and the community. Monitoring the incidence of adverse drug reactions can prevent or reduce the harm experienced by patients and can improve public health. Pharmacists have an important role in drug monitoring, starting from the...
Isnaini Zuliastuti Mubarokah, Fita Rahmawati
Anaemia is a severe problem for chronic kidney failure patients who want to maintain their quality of life. A decrease in erythropoietin production causes anaemia. Erythropoietin therapy is crucial in treating anaemia in chronic kidney failure patients. However, erythropoietin therapy can cause adverse...
The Impact of the COVID-19 Pandemic and Factors Affecting the Mental Health Status of College Students
Nila Sari, Hidayah Karuniawati, Tri Yulianti, Aniq Hudiyah Bil Haq
COVID-19 has become a world pandemic. The number of confirmed cases of COVID-19 has predicted causes of mental health problems, such as depression, anxiety, and stress among students. This study aims to describe the impact of the COVID-19 pandemic and the factors affecting the mental health status of...
Zakky Cholisoh, Ulfa Datrya Fauzi
The objective of this study to review and identify recent studies related to incidence of the extemporaneous compounding products used for pediatric patients. This systematic literature review was conducted by searching the literature using the PubMed and Google Scholar electronic databases between 2016...
Evaluation of the Standard Implementation of Pharmaceutical Services at the Klaten Regency, Indonesia
Zuha Rahma Salsabila, Tri Yulianti
Pharmacy is a place to practice pharmaceutical services carried out by a pharmacist. Pharmaceutical service standards in pharmacies are a benchmark in providing pharmaceutical services for pharmacists. Based on previous research, the implementation of pharmaceutical service standards in several regions...
The Correlation Between Knowledge Level with Attitude and Behavior Toward the Diarrhea Self-medication Among Parents of Toddlers in Parangjoro, Grogol, Sukoharjo, Central Java, Indonesia in 2021
Nuring Novita Kusumawati, Ambar Yunita Nugraheni
Diarrhea is the second leading cause of death in children aged 5 < years worldwide. Diarrhea is also a potential endemic disease of Extraordinary Events (Kejadian Luar Biasa/KLB) followed by mortality in Indonesia. Diarrhea is a disease that can be treated with self-medication. Knowledge affects attitudes...
Identifying Medication-Related Problem in Secondary Stroke Prevention Therapy: A Cross-Sectional Study in Central Java, Indonesia
Hidayah Karuniawati, Zakky Cholisoh, Tanti Azizah Sujono, Laila Nisaul Hekmah
Stroke is the second leading cause of death globally after ischemic heart disease. Patients who survive the first stroke have a possibility to get a recurrent stroke. American Heart Association and the Indonesian Neurologist Association recommend secondary stroke prevention to minimize recurrent stroke....
The Adverse Drug Reactions on Antipsychotic Use in Residual Schizophrenia Outpatients at Hospital in Purworejo, Central Java, Indonesia
Ayu Nissa Ainni, Fita Rahmawati
Residual schizophrenia is a type of schizophrenia with a record of at least one psychotic episode, followed by symptoms that are more prominently negative. Antipsychotic use is the primary therapy, but long-term antipsychotic use affects problems such as Adverse Drug Reactions, resulting in reduced adherence,...
Inhibitory Activity of the α-Glucosidase Enzyme by Albumin Isolated from Giant Gourami (Osphronemus Goramy), Rice Eel (Monopterus albus), and Mackerel Tuna (Euthynnus affinis)
Anifatus Sa’adah, Muhtadi
The giant gourami (Osphronemus goramy), rice eel (Monopterus albus), and mackerel tuna (Euthynnus affinis) are among the sources of protein and albumin that have been used to lower the blood glucose level of people with Diabetes Mellitus (DM). This study aims to determine the protein levels and albumin...
Protein Profiles of Snakehead (Channa striata), Catfish (Pangasius hypopthalmus), and Mackerel (Rastrelliger spp.) and Their Effectiveness as Antidiabetic Agents
Muhammad Sa’ad, Muhtadi
The safety of oral antidiabetic drugs as the first-line therapy for Diabetes Mellitus (DM) has been a prevailing issue. Meanwhile, these drugs are used for long-term treatment and they often require combination therapy. Natural medicine is an alternative to address the safety issue of drugs because of...
Literature Review: Antidiabetic Activities and Phytochemical Screening of Broccoli Plants (Brassica oleracea L. Var. italica)
Alya Chairunnisa, Haryoto
Diabetes mellitus is a metabolic disease that is characterized by hyperglycemia which is closely related to pancreatic β cell dysfunction and insulin resistance. Brassica oleracea L. var. italica is a member of the Brassicaceae family which has antidiabetic properties. These effects are caused by the...
Diyenda Ainun Nida, Haryoto
Pineapple (Ananas comosus L.) is a plant in the Bromeliaceae family that has pharmacological effects such as antimicrobial, anthelmintic, diuretic, antidiabetic, and anticancer properties. This review aims to determine the anticancer activity and action mechanism of pineapple (Ananas comosus L.). The...
Iodination of Isoeugenol Compounds and Its Potential for Therapy of HER-2 Breast Cancer by Molecular Docking
Dadan Suryasaputra, Athina Mardatillah, Putri Nurfadilah
This research used the synthesis of isoeugenol with iodide to improve anticancer activity on the isoeugenol compounds as the first step in the manufacture of radiopharmaceuticals. One of the anticancer mechanisms of isoeugenol is in silico, potentially inhibiting the target molecules on the growth of...
Analysis of Residual Solvents in Co-amoxiclav Coated Tablets Using Solid Phase Microextraction–Gas Chromatography
Dedi Hanwar, Tiara Nur Arsanti, Riesta Primaharinastiti, Mochammad Yuwono
Co-Amoxiclav tablets are coated tablets. The tablet coating process requires an organic solvent in the sealing stage. Several processes are carried out to remove organic solvents in the finished drug product, such as heating and pressure reduction, which still leaves organic solvents in the finished...
Study of Pharmacological Activities and Chemical Content of Rambutan (Nephelium Lappaceum L.) Fruit Peel Extract: A Systematic Review
Anggun Mahirotun Nur Sholikhah, Muhtadi
Indonesia has various types of plants that are efficacious as medicine. One of them is rambutan whose peel has medicinal properties. However, rambutan peel has not been widely used by most people. In recent years, there have been many studies that have tested the effectiveness of rambutan peel on health....
The Use of Celery (Apium Graveolens L.) for Reducing Blood Pressure in Individual with Hypertension in Indonesia: A Review Paper
Rizki Oktarina, Setyaningrum Rahmawaty
Celery (Apium graveolens L.) contains active compounds that can help lowering blood pressure. The purpose of this study was to present an overview of the effectiveness of celery administration in reducing blood pressure of people with hypertention based on studies performed in Indonesia. Two digital...
Anugerah Suciati, Maryati
Galangal (Alpinia galanga) is a plant that is widely spread in Southeast Asia and is widely used for cooking spices. Research related to the effect of A. galanga on cancer cells has been carried out. The purpose of this systematic review is to examine the potential of A. galanga as an anticancer agent...
Pharmacological Activity of Mangrove Plant Bioactive Compounds Against Cancer Cell Changes: A Systematic Review
Dwi Bagus Pambudi, Haryoto
Cancer is a condition when the body's cells begin to grow abnormally and uncontrollably. Cancer therapy which is often used in medicine is non-selective, it can affect other normal cells that have a toxic effect in addition beside the activity as anticancer, to overcome this herbal plants have potential...
Rochmaningsih, Kun Harismah, Akida Mulyaningtyas
Soybeans are the most popular source of vegetable protein for the people of Indonesia, having protein content ranging from 35%–38%. In the protein analysis of 100 mesh size soybean powder using the Kjeldahl method with the Kjeltec 2100 Distilling Unit, the protein content is 35.95. The high protein content...
Atmojo Sandi Utomo, Kun Harismah, Akida Mulyaningtyas
This study develops a selective medium for the growth of Bacillus cereus from soybeans, which can be directly applied in the laboratory to replace media made from meat extract. This study considers the economic aspect by making inexpensive microbiological media, as well as testing the halal aspect so...
Review: Diphenylphosphane Derivatives of Ketoconazole and Oteseconazole/VT-1161, Promising New Azole Compounds in the Treatment of Candida albicans Infections
Muhammad Rosyid As Sabiq, Peni Indrayudha
In some treatments of diseases, there is a risk of possible fungal infection of Candida albicans. The risk of infection can be exacerbated by the occurrence of resistance to anti-fungal drugs, including resistance to azole compounds. The purpose of this research is to conduct a review of new azole compounds...
Diana Shofita Sari, Peni Indrayudha, Maryati, Azis Saifudin, Cita Hanif Muflihah
Cervical cancer was the fourth-highest incidence of female cancer globally in 2020 and the second-highest incidence of female cancer in Indonesia in 2019. Chemotherapy frequently causes side effects and resistance; thus, cancer therapeutic agents must be developed to find selective anticancer drugs....
Cytoxicity of Melinjo (Gnetum Gnemon L.) Seed Protein on MCF-7 and Vero Cells and Its Antiproliferation Activity
Sonia Tithaning Sukma, Peni Indrayudha, Maryati, Azis Saifudin, Cita Hanif Muflihah
Melinjo seeds are one of the plants that have the potential to be developed as anticancer drugs. This study aimed to determine the cytotoxic activity of melinjo seed protein against MCF-7 and vero cells, and to determine the antiproliferative activity of melinjo seed protein against MCF-7 cells. The...
Cytotoxic Activity and Antiproliferation of Soursop Seed (Annona muricata L.) Protein on MCF-7 Cells
Itsna Sofia Rahma, Peni Indrayudha, Maryati, Azis Saifudin, Cita Hanif Muflihah
One of the new anticancer treatments that can be developed is a protein similar to RIPs. RIP is an enzyme found in various parts of plants that is toxic and can inhibit protein synthesis. Soursop seeds (Annona muricata L.) may be developed into anticancer. The plant of the same genus, Annona Squamosa...
Cytotoxic Activity and Antiproliferation of Soursop Seed Protein (Annona muricata) Against 4T1 Cells
Monarita Puspita Dewi, Peni Indrayudha, Maryati, Azis Saifudin, Cita Hanif Muflihah
Current cancer treatments still have a lot of negative impacts, so it is necessary to find alternative treatments that come from nature or plants that have anti-cancer activity. Plants that have the potential to be anti-cancer agents are plants that contain Ribosome-Inactivating Proteins (RIPs). Soursop...
Cytotoxic Activity of Melinjo Seed Protein (Gnetum Gnemon L.) Against 4T1 Cells and Hela Cells, and Antiproliferation Test on 4T1 Cells
Kurnia Indah Fatmawati, Peni Indrayudha, Maryati, Azis Saifudin, Cita Hanif Muflihah
Melinjo (Gnetum gnemon L.) is an easily discovered plant in Indonesia. The previous researchers documented that the Melinjo seed has anticancer activity. This plant contains a high concentration of Ribosome Inactive Proteins (RIPs), which could inhibit protein synthesis. The research aims to determine...
Miah Roney, Md. Sanower Hossain, Mohd Fadhlizil Fasihi Mohd Aluwi
Dengue fever is a growing global health problem, with millions of virus illnesses occurring each year. Unfortunately, there is no approved treatment available. DENV NS5 RdRp protease produced by the dengue virus (DENV) is being investigated as a promising therapeutic target for developing efficient dengue...
Exploring the Genetic Differences Between Small Cell and Non-small Cell Lung Cancer Using Bioinformatic Approaches: A Preliminary Study
Muhammad Amru Nazri, Faris Aizat Ahmad Fajri, Muhamad Harith Zulkifli, Fazlin Mohd Fauzi
Lung cancer can be categorized into two types, which are Non Small Cell Lung Carcinoma (NSCLC) and Small Cell Lung Carcinoma (SCLC). 85% of lung cancer cases are NSCLC, although SCLC is the more aggressive. Mutation of EGFR, ALK and KRAS are characteristics of NSCLC and these findings have led to the...