SNEDDS Formulation for the Combination of Snakehead Fish (Channa striata) and Bitter Melon (Momordica charantia L.) Extract

DOI

10.2991/978-94-6463-050-3_4How to use a DOI?

Keywords

Diabetes Mellitus; Channa striata; Momordica charantia L.; Self-Nanoemulsifying Drug Delivery Systems

Abstract

The combination of Snakehead Fish Powder (SFP) and Bitter Melon Extract (BME) was possible to lower blood sugar levels and antidiabetic agents. The combination of SFP and BME through the mechanism of Self-Nanoemulsifying Drug Delivery Systems (SNEDDS) was carried out. The SNEDDS are forms of lipid-based nanoparticle formulation, which is isotropic mixtures of surfactants, cosurfactants, and oil that spontaneously form nanoemulsions upon contact with gastrointestinal fluids. This study aimed to determine the effect of the composition of surfactants, cosurfactants, and oils, and their comparison in the SNEDDS comprising SFP and BME on emulsification time, transmittance, and nanoemulsion droplet size. The formulation used a total of 30 SNEDDS formulas of SFP and BME was prepared with HLB ranging from 11 to 15 and the combination of surfactant (Tween 20 and Span 80), cosurfactant (glycerin), and oil (olive oil) at ratio 8:1:1, 7:2:1, and 7:1:2. The selected SNEDDS formula combined with SFP and BME was characterized through phase separation, emulsification time, transmittance, nanoemulsion stability, nanoemulsion droplet size, and zeta potential employing a particle size analyzer (PSA). The results showed that 30 SNEDDS formulas were selected and combined with SFP and BME using an HLB of 15 with a combination of surfactants (Tween 20 and Span 80), cosurfactant (glycerin), and oil (olive oil) at ratio 8:1:1. It produced a well-dispersed nanoemulsion in aqueous media with droplet sizes of 212.4 ± 58.10 nm, emulsification time of less than 2 min, and transmittance value of 98.2 ± 1.05%.

Copyright

© 2023 The Author(s)

Open Access

Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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TY  - CONF
AU  - Wa Ode Indah Wulan Hartini Halir
AU  - Muhtadi
AU  - Erindyah Retno Wikantyasning
PY  - 2022
DA  - 2022/12/14
TI  - SNEDDS Formulation for the Combination of Snakehead Fish (Channa striata) and Bitter Melon (Momordica charantia L.) Extract
BT  - Proceedings of the 4th International Conference Current Breakthrough in Pharmacy (ICB-Pharma 2022)
PB  - Atlantis Press
SP  - 29
EP  - 42
SN  - 2590-3195
UR  - https://doi.org/10.2991/978-94-6463-050-3_4
DO  - 10.2991/978-94-6463-050-3_4
ID  - Halir2022
ER  -