Literature Review: Cytotoxic Activity of Pineapple (Ananas comosus L.) Against Cancer Cells

DOI

10.2991/978-94-6463-050-3_18How to use a DOI?

Keywords

Ananas comosus L.; cancer; In vivo; In vitro

Abstract

Pineapple (Ananas comosus L.) is a plant in the Bromeliaceae family that has pharmacological effects such as antimicrobial, anthelmintic, diuretic, antidiabetic, and anticancer properties. This review aims to determine the anticancer activity and action mechanism of pineapple (Ananas comosus L.). The data sources for this review were articles published from 2012 to 2021, which were obtained from Google Scholar and PubMed databases with the keywords cytotoxic; Ananas comosus L.; cancer. The inclusion criteria used original articles or full-text research articles about the potential anticancer activity of pineapple (Ananas comosus L.) through in vivo and in vitro studies published between 2012 and 2021, while the exclusion criteria used were non-full text articles discussing the anticancer activity of pineapple (Ananas comosus L.). The search results on Google Scholar and PubMed search engines yielded a total of 594 articles, of which 468 articles were published within the last 10 years. Then, the articles obtained were identified, resulting in 8 articles that met the inclusion and exclusion criteria. The results of the analysis showed that pineapple (Ananas comosus L.) has anticancer activity from secondary metabolites, namely flavonoids and bromelain enzymes contained in pineapple (Ananas comosus L.). Bromelain and flavonoids in pineapple plants have anticancer activity by inducing apoptosis in cancer cells through p53 induction mechanisms, upregulation of Bcl-2 which is an anti-apoptotic protein, upregulation of Bax which is pro-apoptotic protein, induction of caspases, decreased expression of COX2, and regulating the MAPK and Akt/PKB pathway to inhibit NF-kB pathway.

Copyright

© 2023 The Author(s)

Open Access

Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

Download article (PDF)

TY  - CONF
AU  - Diyenda Ainun Nida
AU  - Haryoto
PY  - 2022
DA  - 2022/12/14
TI  - Literature Review: Cytotoxic Activity of Pineapple (Ananas comosus L.) Against Cancer Cells
BT  - Proceedings of the 4th International Conference Current Breakthrough in Pharmacy (ICB-Pharma 2022)
PB  - Atlantis Press
SP  - 210
EP  - 226
SN  - 2590-3195
UR  - https://doi.org/10.2991/978-94-6463-050-3_18
DO  - 10.2991/978-94-6463-050-3_18
ID  - Nida2022
ER  -