Protein Profiles of Snakehead (Channa striata), Catfish (Pangasius hypopthalmus), and Mackerel (Rastrelliger spp.) and Their Effectiveness as Antidiabetic Agents

DOI

10.2991/978-94-6463-050-3_16How to use a DOI?

Keywords

Channa striata; Pangasius hypopthalmus; Rastrelliger spp; α-glucosidase

Abstract

The safety of oral antidiabetic drugs as the first-line therapy for Diabetes Mellitus (DM) has been a prevailing issue. Meanwhile, these drugs are used for long-term treatment and they often require combination therapy. Natural medicine is an alternative to address the safety issue of drugs because of its minimal side effects and abundant availability. One of the alternatives is snakehead (Channa striata), which has been reported to have antidiabetic activity derived from the regeneration of the damaged pancreatic islets of Langerhans. In addition, snakehead fish is a source of amino acids that lower the accumulation of blood glucose. This study aimed to examine the protein profiles and antidiabetic activity of catfish (Pangasius hypopthalmus) and mackerel (Rastrelliger spp) and to determine their capacities as alternatives to snakehead. The albumin measurements showed that the albumin levels of snakehead, catfish, and mackerel were 4.84 ± 0.54%, 2.57 ± 0.29%, and 2.39 ± 0.29%, respectively. The proximate analysis showed a protein content of 11.8%, 13.58%, and 16.93%, respectively. The screening of α-glucosidase inhibitory activity obtained that the inhibitory activities of the samples were lower than that of acarbose as the control (p < 0.05). Interestingly, all the samples indicated a similar pattern in α-glucosidase inhibitory activity, of which the hydrolysate had a higher potency than the albumin, and the albumin was higher than the powder content (p < 0.05). Briefly, catfish and mackerel can be the alternatives to snakehead to support the management of DM therapy.

Copyright

© 2023 The Author(s)

Open Access

Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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TY  - CONF
AU  - Muhammad Sa’ad
AU  - Muhtadi
PY  - 2022
DA  - 2022/12/14
TI  - Protein Profiles of Snakehead (Channa striata), Catfish (Pangasius hypopthalmus), and Mackerel (Rastrelliger spp.) and Their Effectiveness as Antidiabetic Agents
BT  - Proceedings of the 4th International Conference Current Breakthrough in Pharmacy (ICB-Pharma 2022)
PB  - Atlantis Press
SP  - 189
EP  - 197
SN  - 2590-3195
UR  - https://doi.org/10.2991/978-94-6463-050-3_16
DO  - 10.2991/978-94-6463-050-3_16
ID  - Sa’ad2022
ER  -