Epigenetic Regulations, Motif and Pathway Identification of Hodgkin Lymphoma Chip Sequence

DOI

10.2991/978-94-6463-164-7_11How to use a DOI?

Keywords

Classical Hodgkin lymphoma; Epstein barr virus; Hodgkin lymphoma; Insulin-like growth factor; Lymphocyte-rich Hodgkin lymphoma; Reed-Sternberg cells; Chromatin immunoprecipitation sequencing; National Centre for Biotechnology Information; Binary Alignment Map format; FASTA/BLAST format; Sequence Read Archive; B-cell lymphoma 6 protein; Fast Alignment sequence test for application; European Bioinformatics Institute; Gene Expression Omnibus Genome Analyzer; Kyoto Encyclopedia of Genes and Genomes pathway database

Abstract

ChIP-sequencing (Chromatin immunoprecipitation) is a new method for genome wide mapping of protein binding sites on DNA. ChIP-sequencing helps to understand better the mechanisms of transcription factors, cofactors and histone modifications as well the regulation of gene expressions. The high degree of flow rate of sequencing data can be retrieved through international data repositories that is NCBI Sequence Read Archive (SRA). The BCL6 proto- oncogene encodes a nuclear transcriptional repressor. BCL6 suppresses p53 in germinal center, where the deregulation of BCL6 is located contributes to the malignant transformation in germinal center derived B cells. Hodgkin lymphoma arises from germinal center derived B cell. Epigenetics is the study of genetic changes in gene activity which are generally caused by mechanisms other than DNA sequence changes. For studying epigenomics data, bioinformatics is a successful approach in the field of molecular biology.

Copyright

© 2023 The Author(s)

Open Access

Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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TY  - CONF
AU  - Priyanka Stephen Mukhia
AU  - I. A. Shylesh Murthy
AU  - Preenon Bagchi
PY  - 2023
DA  - 2023/06/05
TI  - Epigenetic Regulations, Motif and Pathway Identification of Hodgkin Lymphoma Chip Sequence
BT  - Proceedings of the Joint 3rd International Conference on Bioinformatics and Data Science (ICBDS 2022)
PB  - Atlantis Press
SP  - 132
EP  - 146
SN  - 2468-5739
UR  - https://doi.org/10.2991/978-94-6463-164-7_11
DO  - 10.2991/978-94-6463-164-7_11
ID  - Mukhia2023
ER  -