Proceedings of the Joint 3rd International Conference on Bioinformatics and Data Science (ICBDS 2022)
R. Somashekhar, Preenon Bagchi, T. S. Rajesh, Richard Hill, Kathryn Rossi
Yegnanarayanan Venkataraman, T. Kalaiselvi, Jeyaraj Jane Rubel Angelina, Subhashini Sottallu Janakiram
Protein-Protein interactions (PPIs) are vital for explaining the structural and functional architecture of the cell. To have a wider comprehension of the mechanisms, finding driver proteins that are vital for the control of the said network is a pertinent task in systems biology. Lately, it has become...
S. Suba, Nita Parekh, Ramesh Loganathan, Vikram Pudi, Chinnababu Sunkavalli
Computer tomography (CT) have been routinely used for the diagnosis of lung diseases and recently, during the pandemic, for detecting the infectivity and severity of COVID-19 disease. One of the major concerns in using machine learning (ML) approaches for automatic processing of CT scan images in clinical...
Anjali Jha, I. A. Shylesh Murthy, Preenon Bagchi
Schizophrenia is a chronic, severe mental disorder that affects the way a person thinks, acts, expresses emotions, perceives reality, and relates to others. Metatranscriptomics analysis enables understanding of how the micro biome responds to the environment by studying the functional analysis of genes...
Identification of Expressed, Mutated Genes and Binding Sites of DNA Associated Proteins in Alzheimer’s Disease
V. Maruthi Raj, Preenon Bagchi
Background: A neurodegenerative disorder in the elderly individuals. It is a type of dementia that affects memory subsequently followed by executive dysfunction, confusion, agitation, and behavioral disturbances. Three causative genes have been associated with autosomal dominant familial AD (APP, PSEN1,...
Establishing Phylogenetic Profile and Identification of Function and Ligands for Mycobacterium Ulcerans Microbiome
G. Arpitha, Preenon Bagchi
Buruli ulcer is caused primarily by Mycobacterium ulcerans. Due to its high association with the Buruli ulcer, Mycobacterium ulcerans microbiota were used in the study. This microbiota taxon and functional profile have been identified thanks to advances in Metatranscriptomic Sequencing. Then there are...
Rushikesh Shelke, I. A. Shylesh Murthy, Preenon Bagchi
Schizophrenia is a chronic psychiatric disorder with a heterogeneous genetic and neurobiological background, it is one of the mental disorder which is common all over the world. Genes associated with Schizophrenia are DRD2, ERBB4, GRIA1, GRIN2A, GRM3. Among its related pathways/superpathways are Dopaminergic...
Multiple Case Analysis on Work-Family Conflict and Financial Stressors Among COVID Survived Newlyweds
Christina Mariam Chacko, Sonia George
India’s marital culture is evolving. Relationship boundaries are becoming more diffused as a result of nuclear families, women being monetarily independent, and a reduction in social inhibitions. Due to COVID-19, there was a rapid change in the workplace environment where the line between the work and...
Kushagra Agarwal, Nita Parekh
In this study we carried out a comprehensive analysis of SARS-CoV-2 mutations and their spread in India over the past two years of the pandemic (27th Jan’ 2020 – 8th Mar’ 2022). The analysis covers four important timelines, viz., the early phase, followed by the first, second and third waves of the pandemic...
Epigenetic Regulations, Motif and Pathway Identification of Gabaergic Neurotransmitter’s Chip Sequence
I. A. Shylesh Murthy, Preenon Bagchi
Background: The next generation techniques has revolutionalized the biology era. In this work we are using Chromatin immunoprecipitation (ChiP) technique on the ChIP–seq of Gamma-Amino Butyric Acid (GABA). GABA is a brain-made chemical. It also found in some foods. The effect of GABA in brain is anti-seizure...
Priyanka Stephen Mukhia, I. A. Shylesh Murthy, Preenon Bagchi
ChIP-sequencing (Chromatin immunoprecipitation) is a new method for genome wide mapping of protein binding sites on DNA. ChIP-sequencing helps to understand better the mechanisms of transcription factors, cofactors and histone modifications as well the regulation of gene expressions. The high degree...
M. Swathi, Milan Khandelwal, Preenon Bagchi
Sandhoff’s disease is a lysosomal disorder. It’s an inherited lipid storage disease. Progressively destroys the nerve cells in brain and spinal cord. It’s a rare inherited disorder. Which is commonly seen in infants. Here I took the HEXB gene from Sandhoff’s disease because we did motif analysis and...
Establishing the Taxa with Phylogenetic Profile and in-silico-ayurvedic Remedy of Colon Cancer Microbiome
Sai Divya Paggala, I. A. Shylesh Murthy, Preenon Bagchi
The discovery of a bacterium, Helicobacter pylori that is resident in the human stomach chronic disease (peptic ulcer and gastric cancer) was radical on many levels. Studies of this genetic diversity in strains isolated from various locations across the globe. The goal of this study was to determine...
Establishing the Taxa with Phylogenetic Profile and in-silico-ayurvedic Remedy of Microbiome of Bacterial Vaginosis
S. Geethashree, I. A. Shylesh Murthy, Preenon Bagchi
Background: Bacterial vaginosis (BV) is a vaginal disease commonly caused by bacteria which most commonly causes abnormal vaginal discharge during women’s reproductive-age. BV is characterized by a shift within the vaginal flora from the dominant Lactobacillus to a polymicrobial flora and is further...
Establishing the Taxa with Phylogenetic Profile and in-silico Ayurvedic Remedy of Cervicitis Microbiome
Milan Khandelwal, I. A. Shylesh Murthy, Preenon Bagchi
Cervicitis is an inflammation of the cervix, the lower, narrow end of the uterus that opens into the vagina. Basically, it causes inflammation of the uterine cervix. Cervicitis is a clinical syndrome characterised by inflammation of primarily the columnar epithelium of the uterine endocervix. The bacteria...
Identification of Taxa and Functional Pathway Information of Mycobacterium tuberculosis Microbiome and High Throughput Simulation Studies with Mycobacteriophage
Divya Verma, I. A. Shylesh Murthy, Preenon Bagchi
Tuberculosis caused by bacteria Mycobacterium tuberculosis. The bacteria usually attack the lungs, but TB bacteria can attack any part of the body such as the kidney, spine and brain. Mycobacterium tuberculosis in lungs microbiome can be studied by metamorphic mechanization specifically metatransriptomics...
B. S. Anusha, Preenon Bagchi
Background: Nipah virus encephalitis causing microbiome Nipah henipavirus was taken in this work which is the causative factor for encephalitis condition in humans. The fruit bats of Pteropus genus are the natural reservoir and acts as a carrier of this Nipah henipavirus. The phylogeny, functional profile...
D. V. Sriharsha, Nandhini Nagarajan, Soumya Prabhakar Murthy, Lekshmi Uday Nair, Preenon Bagchi
Introduction: Nanotechnology has received a lot of attention in recent years because of its wide range of applications in all scientific fields. Agriculture could benefit from the use of nanoparticles. In today’s world, sustainable agriculture is essential. Smartly designed nanoparticles, such as nanozeolites,...
Venkataramanan Swaminathan, Tamilambikai Parandaman, Kavitha Kannan, Norfatiha Binti Bawahi, K. M. Kumar
Lung adenocarcinoma is an imminent principal cancer that causes a huge number of mortality for both men and women because of the respiratory epithelium. The survival rate analysis of patients improved year by year by using bioinformatics tools. The purpose of this research aimed to investigate the PPI...
A. Vijaya Lakshmi, Perike Chandra Sekhar, K. Suresh Joseph, A. Sai Priya
Ambulance Routing Problem (ARP) is the part of Emergency Medical Services (EMS), which provide timely medical help for those who are in need. In Medical emergency situation, the key concern is, to provide early treatment. Relocating patients quickly to neighboring medical facilities is extremely difficult...