Proceedings of the 7th International Conference on Biological Science (ICBS 2021)

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The Potency of Inulin to Increase Curcumin Aqueous Solubility as a Co-Processing Material with Curcuma longa in Solid Dispersion Approach

Authors
Dewi Setyaningsih1, *, Elizabeth Vianita Kurniawan1, Yustina Sri Hartini1
1Faculty of Pharmacy, Paingan Maguwoharjo Depok Sleman Sanata Dharma University, Yogyakarta, Indonesia
*Corresponding author. Email: dewi@usd.ac.id
Corresponding Author
Dewi Setyaningsih
Available Online 2 May 2022.
DOI
10.2991/absr.k.220406.046How to use a DOI?
Keywords
Curcuminoids; Dissolution; Extracts; Spray drying
Abstract

Curcumin, an identical compound of Curcuma longa extract, shows limited bioavailability due to its lipophilicity. Inulin of degree of polymerization (DP) of 11 is a carbohydrate member that can potentially increase aqueous solubility and dissolve lipophilic compounds. This study aimed to investigate inulin DP 11 at various drug loads of curcumin on the solubility and dissolution of curcumin. The inulin and C. longa extract were co-processed using a solid dispersion (SD) technology on a spray dryer and were analyzed for curcumin solubility as well as dissolution. The drug content (drug load) of SD formulations was prepared at 10%-30% w/w. As the control, the corresponding drug load was designed without applying the SD technology, called physical mixture (PM) formulations. The results suggest that employing the SD technique, inulin DP 11 co-processed with curcumin enhances the aqueous solubility of curcumin compared to the corresponding PM formulations. The dissolution as analyzed for dissolution efficiency (DE) of the SD samples was enhanced by factors 1.7, 2.9, and 3.3 for the drug load of 10%, 20%, and 30% w/w, respectively. To conclude, inulin DP 11 is favorable to enhance curcumin aqueous solubility and dissolution using am SD platform.

Copyright
© 2022 The Authors. Published by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license.

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Volume Title
Proceedings of the 7th International Conference on Biological Science (ICBS 2021)
Series
Advances in Biological Sciences Research
Publication Date
2 May 2022
ISBN
10.2991/absr.k.220406.046
ISSN
2468-5747
DOI
10.2991/absr.k.220406.046How to use a DOI?
Copyright
© 2022 The Authors. Published by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license.

Cite this article

risenwbib
TY  - CONF
AU  - Dewi Setyaningsih
AU  - Elizabeth Vianita Kurniawan
AU  - Yustina Sri Hartini
PY  - 2022
DA  - 2022/05/02
TI  - The Potency of Inulin to Increase Curcumin Aqueous Solubility as a Co-Processing Material with Curcuma longa in Solid Dispersion Approach
BT  - Proceedings of the 7th International Conference on Biological Science (ICBS 2021)
PB  - Atlantis Press
SP  - 327
EP  - 330
SN  - 2468-5747
UR  - https://doi.org/10.2991/absr.k.220406.046
DO  - 10.2991/absr.k.220406.046
ID  - Setyaningsih2022
ER  -