Bioinformatics Analysis on Molecular Mechanism of Poria Cocos in Treatment of Jaundice
Shan Si, Nie Peng, Jiang Li, Yuwen Yan, Xiaojun Yan
Available Online September 2016.
- https://doi.org/10.2991/iccia-16.2016.4How to use a DOI?
- Poria Cocos; Jaundice; IPA; PubChem.
- Objective: To study the molecular mechanism of P.cocos in the treatment of Jaundice by building molecular networks and comparing canonical pathways. Methods: Target proteins of P.cocos related genes of Jaundice were searched from Pubchem and Gene databases online respectively. Molecular networks and canonical pathways comparison analyses were performed by IPA. Results: The molecular networks of P.cocos and Jaundice were complex and multifunctional. The 14 target proteins of P.cocos and 33 Homo sapiens genes of Jaundice were found in databases. There were 56 common pathways both related networks. P.cocos could regulate endothelial differentiation Tumor Necrosis Factor (TNF), Interleukin-1 (IL-1 ) and Interleukin-6 (IL-6) in these pathways. Conclusions: P.cocos treat Jaundice by regulatingmany effective nodes of Metabolism pathway and Immunity related pathways.
- Open Access
- This is an open access article distributed under the CC BY-NC license.
Cite this article
TY - CONF AU - Shan Si AU - Nie Peng AU - Jiang Li AU - Yuwen Yan AU - Xiaojun Yan PY - 2016/09 DA - 2016/09 TI - Bioinformatics Analysis on Molecular Mechanism of Poria Cocos in Treatment of Jaundice BT - Proceedings of the 2016 International Conference on Computer Engineering, Information Science & Application Technology (ICCIA 2016) PB - Atlantis Press SP - 18 EP - 22 SN - 2352-538X UR - https://doi.org/10.2991/iccia-16.2016.4 DO - https://doi.org/10.2991/iccia-16.2016.4 ID - Si2016/09 ER -