Garlic (Allium sativum L.) Efficacy as an Adjuvant Therapy for Type 2 Diabetes Mellitus: A Scoping Review

DOI

10.2991/978-94-6463-048-0_49How to use a DOI?

Keywords

efficacy; Allium sativum L.; adjuvant therapy; T2DM

Abstract

Type 2 Diabetes Mellitus (T2DM) is a chronic disease with increasing prevalence worldwide and causing many threatening life complications. Various alternative therapies continue to be developed to control blood sugar level in T2DM, including from tradisional plants. Garlic (Allium sativum L.) is a traditional plant that is easily obtained at relatively low cost. Many preclinical and clinical studies have shown the capability of Allium sativum L. to inhibit T2DM pathophysiology. This scoping review was aimed to know the efficacy of Allium sativum L. as adjuvant therapy for T2DM patients. Articles used for this review were original articles about Allium sativum L. adjuvant intervention for T2DM patients, published in 2011–2021, and in English or Indonesian language. Databases used were EBSCO, Google Scholar, PubMed, ScienceDirect, ProQuest, Taylor & Francis Online, Ovid, Springer Link, Portal Garuda, OneSearch, and Neliti, with Boolean search. The articles in the search results were selected by PRISMA-ScR. Selected articles were extracted, pointed, then synthesized to answer the review goal. Review process from six selected articles have shown that administration of 500–900 mg/day Allium sativum L. combined with metformin for 12- or 24-weeks improved blood glucose, ADA, hs-CRP, and lipid profile significantly. However, intervention of Allium sativum L. in less than 12 weeks, did not improve the result significantly. Enteric-coated and odorless tablet preparation of Allium sativum L. is recommended to prevent digestive disturbances from Allium sativum L. This scoping review showed that administration of 500–900 mg/day Allium sativum L. for 12 or 24 weeks, showed efficacy for T2DM as an adjuvant therapy with still considering patient clinical conditions and adverse events that may be occurred.

Copyright

© 2023 The Author(s)

Open Access

Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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TY  - CONF
AU  - Hafidz Abdullah
AU  - Isnatin Miladiyah
PY  - 2022
DA  - 2022/12/19
TI  - Garlic (Allium sativum L.) Efficacy as an Adjuvant Therapy for Type 2 Diabetes Mellitus: A Scoping Review
BT  - Proceedings of the 3rd International Conference on Cardiovascular Diseases (ICCvD 2021)
PB  - Atlantis Press
SP  - 419
EP  - 434
SN  - 2468-5739
UR  - https://doi.org/10.2991/978-94-6463-048-0_49
DO  - 10.2991/978-94-6463-048-0_49
ID  - Abdullah2022
ER  -