The Effects of Subtotal Nephrectomy Method on Urea and Creatinine Serum in Hypertension Animal Model

DOI

10.2991/978-94-6463-048-0_26How to use a DOI?

Keywords

Hypertension; Urea; Creatinine

Abstract

Chronic kidney failure is a disease that causes a decrease in kidney function in cleaning the blood of toxic materials, which causes accumulation of metabolic waste in the blood. Renal failure can cause severe azotemia and uremia. Subtotal nephrectomy is a method to induce hypertension and renal failure. This research is a laboratory experiment study using serum from 30 rats that have been treated. The positive control group was (one kidney was removed and giving 3% NaCl solution), 5/6 subtotal nephrectomy group (kidney was removed 5/6), the negative control group was (Shame operated). Urea and Creatinine levels will be checked using spectrophotometry. The data analysis used a one way ANOVA test. The average urea level (mg/dl) in the negative control group was 20.39 ± 2.59, while the positive control group obtained an average of 31.78 ± 6.15, and the 5/6 nephrectomy group obtained an average urea level of 33.17 ± 7.34. For creatinine levels (mg/dl), the mean of the negative control group was 1.12 ± 0.41; the positive control group was 1.64 ± 0.24 and in the 5/6 nephrectomy group 1.63 ± 0.17. A P-value of urea and creatinine levels was p < 0.05, which means that there are differences in urea and creatinine levels in experimental animal models of hypertension with the 5/6 sub nephrectomy method. In conclusion, there are significant differences in urea and serum creatinine between sub nephrectomy method and control groups.

Copyright

© 2023 The Author(s)

Open Access

Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

Download article (PDF)

TY  - CONF
AU  - Ernadita Budiastuti
AU  - Miranti Dewi Pramaningtyas
PY  - 2022
DA  - 2022/12/19
TI  - The Effects of Subtotal Nephrectomy Method on Urea and Creatinine Serum in Hypertension Animal Model
BT  - Proceedings of the 3rd International Conference on Cardiovascular Diseases (ICCvD 2021)
PB  - Atlantis Press
SP  - 230
EP  - 234
SN  - 2468-5739
UR  - https://doi.org/10.2991/978-94-6463-048-0_26
DO  - 10.2991/978-94-6463-048-0_26
ID  - Budiastuti2022
ER  -