The Potential of Black Cumin SNEDDS (Self-nanoemulsifying Drug Delivery System) on Total Cholesterol Level of Hypercholesterolemic Model Zebrafish (Danio Rerio)

DOI

10.2991/978-94-6463-048-0_38How to use a DOI?

Keywords

Hypercholesterolemia; zebrafish; black cumin seeds oil; SNEDDS

Abstract

Hypercholesterolemia is a risk factor for various cardiovascular diseases. This condition is marked by the increasing total cholesterol level higher than 200 mg/dL. Black cumin is one of the herbal plants which has the potential to be an antihyperlipidemic agent. Black cumin used in this research is SNEDDS-based, which can increase drug bioavailability. This study aims to determine the effect of SNEDDS-based Black Cumin on Zebrafish total cholesterol levels. This is quasi-experimental research with pre-test and post-test nonequivalent control group design. The research subjects were divided into four groups: a positive control group (Simvastatin 20 mcg/g feed), a negative control group (without intervention), Intervention 1/P1 (25 ppm SNEDDS), and Intervention 2/P2 (50 ppm SNEDDS). The obtained data were analyzed with Shapiro-Wilk Test, Kruskal-Wallis Test, and Wilcoxon Test. Total cholesterol level decreased significantly in the P1 group, with the total cholesterol pre and post-test difference up to 100.4 ± 81.89 and p-value 0.043 (p < 0.05). Otherwise, in the P2 group, the positive control group, and the negative control group did not show any significant differences between pre and post-test total cholesterol levels with the p-value 0.345 (p > 0.05), 0.5 (p > 0.05), and 0.686 (p > 0.05) respectively. Black Cumin SNEDDS, which has a concentration of 25 ppm, can decrease total cholesterol levels on hypercholesterolemic zebrafish.

Copyright

© 2023 The Author(s)

Open Access

Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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TY  - CONF
AU  - Annisa Sofiana
AU  - Rizki Fajar Utami
PY  - 2022
DA  - 2022/12/19
TI  - The Potential of Black Cumin SNEDDS (Self-nanoemulsifying Drug Delivery System) on Total Cholesterol Level of Hypercholesterolemic Model Zebrafish (Danio Rerio)
BT  - Proceedings of the 3rd International Conference on Cardiovascular Diseases (ICCvD 2021)
PB  - Atlantis Press
SP  - 328
EP  - 335
SN  - 2468-5739
UR  - https://doi.org/10.2991/978-94-6463-048-0_38
DO  - 10.2991/978-94-6463-048-0_38
ID  - Sofiana2022
ER  -