Genetic pattern of CYP1A1*2A (T>C) gene in patients with colorectal cancer in South Jakarta – Indonesia

DOI

10.2991/ichlas-17.2017.5How to use a DOI?

Keywords

CYP1A1*2A, colorectal cancer, Indonesia

Abstract

The information of relationship between genetics and cancer in Indonesia, especially colon cancer, is still limited. This study aimed to determine the genetic pattern of colon cancer allele in Fatmawati Hospital, Jakarta -Indonesia. We conducted a case-control study of 40 colorectal cancer patients and 133 volunteers as controls. We observed CYP1A1*2A alleles using RFLP-PCR method. Three milliliters of blood was used to isolate DNA. Our observation showed of the genetic patterns CYP1A1*2A with the incidence of colorectal cancer showed 17 patients were variant-type homozygote and 12 patients were heterozygote type. Conclusions: In this research shown the common of genotyping type CYP1A1*2A of colorectal cancer from the patients are a heterozygous variant type.

Copyright

© 2017, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Chris Adhiyanto
AU  - Witri Ardini
AU  - Hoirun Nisa
AU  - Zeti Harriyati
AU  - Suryani
AU  - Dina A. Amu
AU  - Kemal A.L. Fajar
AU  - Taslim  Poniman
AU  - Rofi  Saunar
AU  - W.  Aditomo
PY  - 2017/12
DA  - 2017/12
TI  - Genetic pattern of CYP1A1*2A (T>C) gene in patients with colorectal cancer in South Jakarta – Indonesia
BT  - Proceedings of the 1st International Integrative Conference on Health, Life and Social Sciences (ICHLaS 2017)
PB  - Atlantis Press
SN  - 2468-5739
UR  - https://doi.org/10.2991/ichlas-17.2017.5
DO  - 10.2991/ichlas-17.2017.5
ID  - Adhiyanto2017/12
ER  -