Proceedings of the 1st International Integrative Conference on Health, Life and Social Sciences (ICHLaS 2017)

The Effect of Ethanolic Extract of Olive (Olea europea L.) Leaves on BALB/c Mice

Authors
Nurul Hiedayati, Nurlaely M. Rachmawati, Riva Auda, M. Iqbal Dzaki, Nihayatul Kamila, Aris Purnomo
Corresponding Author
Nurul Hiedayati
Available Online December 2017.
DOI
https://doi.org/10.2991/ichlas-17.2017.29How to use a DOI?
Keywords
Acute toxicity; olive leaves
Abstract
Olives has been mentioned in holly books, Quran and Bible, as medicinal and good nutritional food. People using it as a herbal medicine for centuries. However, we concern about its toxicity to some organs tissues. In this study, we observed histopathological changes on stomach, liver and kidney tissues of BALB/c mice after administrated with ethanolic extract of olive leaves (OLE). Male BALB/c mice were divided into three groups. Each group subsequently orally administrated with phosphate buffer saline (group-I), or OLE (100 mg/kg (group-II); 200 mg/kg (group-III)) for ten consecutive days before necropsy. Mice were sacrificed next day and stomach, liver and kidney tissue were observed for histopathological changes using hematoxyline-eosin. Observation using Corel Photo PX7. Stomach mucosal epithelial damage were 1.9%, 3.2% and 1.7%, hepatocyte damages were 40%, 38.1%, 63,1%, Glomerular atrophy were 11.5%, 9.9% and 11,5%, kidney tissue bleeding area were 3.7%, 3.1%, 4.1% in group-I, -II and –III respectively. Ethanolic extract of local olive leaves have mucoprotective activity on stomach tissues, but at 200 mg/kg have a toxic effect on mice liver and kidney tissues.
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This is an open access article distributed under the CC BY-NC license.

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Proceedings
1st International Integrative Conference on Health, Life and Social Sciences (ICHLaS 2017)
Part of series
Advances in Health Sciences Research
Publication Date
December 2017
ISBN
978-94-6252-422-4
ISSN
2468-5739
DOI
https://doi.org/10.2991/ichlas-17.2017.29How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - CONF
AU  - Nurul Hiedayati
AU  - Nurlaely M. Rachmawati
AU  - Riva Auda
AU  - M. Iqbal Dzaki
AU  - Nihayatul Kamila
AU  - Aris Purnomo
PY  - 2017/12
DA  - 2017/12
TI  - The Effect of Ethanolic Extract of Olive (Olea europea L.) Leaves on BALB/c Mice
BT  - 1st International Integrative Conference on Health, Life and Social Sciences (ICHLaS 2017)
PB  - Atlantis Press
SN  - 2468-5739
UR  - https://doi.org/10.2991/ichlas-17.2017.29
DO  - https://doi.org/10.2991/ichlas-17.2017.29
ID  - Hiedayati2017/12
ER  -