Mathematical Modeling of Dynamics of Gene Expression Levels Circadian Rhythm

DOI

10.2991/ichw-19.2019.4How to use a DOI?

Keywords

mathematical modelling, dynamics of circadian rhythm, genes' expression, levels

Abstract

The present study focuses on mathematical modeling of the dynamics of gene expression levels of circadian rhythm. All living organisms exhibit daily (circadian) rhythms. At first glance, there is a feeling that circadian rhythms caused by external reasons, but they exist offline: these processes are innate, are of endogenous origin, i.e. do not occur exclusively in response to external stimuli, and are generated within the body. One such process is gene expression. The object of the research work are the expression levels of genes associated with circadian rhythms. The subject of research is the nature of change of gene expression levels in different conditions of sleep. The process focuses on coexpression (i.e., the relationship between expression levels of different genes). To solve this problem it is necessary to assess the coordination of gene expression using the Pearson correlation and to compensate for the different number of samples in the groups due to the transition to the levels of statistical significance (p-value). The study of the effect of insufficient sleep on circadian rhythmicity and changes in the expression of the transcriptome of human blood is of great interest. Despite recent technological advances in this field, the study of the human transcriptome is still in its early stages. Mechanisms resulting in negative health consequences as a result of insufficient sleep, remain uncertain. Molecular basis physiological effects of shift circadian rhythms is still not fully understood. Research devoted to identifying the role of sleep duration in the change in the dynamics of gene expression levels of circadian rhythm, are of great importance for clinical applications

Copyright

© 2019, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Darna Badgaeva
PY  - 2019/10
DA  - 2019/10
TI  - Mathematical Modeling of Dynamics of Gene Expression Levels Circadian Rhythm
BT  - Proceedings of the International Conference on Health and Well-Being in Modern Society (ICHW 2019)
PB  - Atlantis Press
SP  - 15
EP  - 18
SN  - 2468-5739
UR  - https://doi.org/10.2991/ichw-19.2019.4
DO  - 10.2991/ichw-19.2019.4
ID  - Badgaeva2019/10
ER  -