Proceedings of the International Conference on Health and Well-Being in Modern Society (ICHW 2019)

The Research of Neutrophil Extracellular Traps in the Blood of Women with Malignization of Cervical Epithelium

Authors
E. Kayukova, L. Sholokhov, T. Belokrinitskaya
Corresponding Author
E. Kayukova
Available Online October 2019.
DOI
https://doi.org/10.2991/ichw-19.2019.33How to use a DOI?
Keywords
cervical cancer, neutrophil extracellular traps, cancerogenesis
Abstract
Neutrophil extracellular traps (NETs) are destroyed neutrophils combined with DNA, proteins, and enzymes; they are the destruction mechanisms of a cell attacked by pathogens. Currently its pathophysiological contribution to the neoplastic process remains controversial. The aim is to determine the number of NETs in the blood of women with cervical cells malignization. The research covered 21 cases - 7 women with cervical premalignancies (I group) and 14 women with cervical cancer of stages 0-III (II group). The average age of patients was 38±8.26. The control group was formed of volunteers without cervical pathologies (n=10). Blood serum was used as the material for the research. Neutrophils, monocytes, and NETs were counted in Feulgen stained blood smears by the optical microscope. The count was performed per 100 cells. In addition, we performed retrospective analysis of some blood parameters of the examined individuals. NETs were not found in the blood of healthy women and women with premalignancies. NETs were observed in the blood of 70% of patients with cervical cancer. The maximum number was found in the blood of patients with stage IIb cancer. Leukocytosis was registered in the blood of the patients diagnosed with cervical cancer due to neutrophilia and lymphopenia. The discovered changes increased as the neoplastic process aggravated. The results of the study and literature data point to the existing changes in blood neutrophils of the patients with cervical cancer and NETs participation in cervical carcinogenesis which requires further research.
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This is an open access article distributed under the CC BY-NC license.

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Volume Title
Proceedings of the International Conference on Health and Well-Being in Modern Society (ICHW 2019)
Series
Advances in Health Sciences Research
Publication Date
October 2019
ISBN
978-94-6252-820-8
ISSN
2468-5739
DOI
https://doi.org/10.2991/ichw-19.2019.33How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - CONF
AU  - E. Kayukova
AU  - L. Sholokhov
AU  - T. Belokrinitskaya
PY  - 2019/10
DA  - 2019/10
TI  - The Research of Neutrophil Extracellular Traps in the Blood of Women with  Malignization of Cervical Epithelium
BT  - Proceedings of the International Conference on Health and Well-Being in Modern Society (ICHW 2019)
PB  - Atlantis Press
SP  - 137
EP  - 141
SN  - 2468-5739
UR  - https://doi.org/10.2991/ichw-19.2019.33
DO  - https://doi.org/10.2991/ichw-19.2019.33
ID  - Kayukova2019/10
ER  -