Proceedings of the International Conference “Health and wellbeing in modern society” (ICHW 2020)

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Inclusion Complexes of Cyclodextrins With Biologically Active Molecules in Water-Organic Solvents as a Promising Material for the Pharmaceutic Industry

Authors
T.R. Usacheva, D.N. Kabirov, Lan Pham Thi, E.L. Isaeva, E.R. Aslambekova, Z.S. Hasbulatova
Corresponding Author
D.N. Kabirov
Available Online 3 October 2020.
DOI
10.2991/ahsr.k.201001.036How to use a DOI?
Keywords
cyclodextrins, benzoic acid, water-ethanol solvent, isothermal titration calorimetry, complex formation, solvation
Abstract

The paper provides the review of literature sources on thermodynamics of inclusion complexes reactions of cyclodextrin with biologically active hydrophobic molecules. The group of authors presents the results of their experimental studies of the inclusion complexes reaction of β-cyclodextrin (β-CD) with benzoic acid (BA) in water-ethanol solvents. Thermodynamic parameters of the reaction [BAβCD] are defined. In the transition from water to water-ethanol mixtures, the stability of the complex decreases, while the exothermicity of the reaction increases. The results were discussed on the basis of solvation-thermodynamic approach. The most popular application is the pharmaceutical industry, since this is connected with the development of vector delivery of medicines to living systems, which makes it possible not only to significantly increase the efficiency of the drug used, but also to significantly improve its consumer properties.

Copyright
© 2020, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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Volume Title
Proceedings of the International Conference “Health and wellbeing in modern society” (ICHW 2020)
Series
Advances in Health Sciences Research
Publication Date
3 October 2020
ISBN
10.2991/ahsr.k.201001.036
ISSN
2468-5739
DOI
10.2991/ahsr.k.201001.036How to use a DOI?
Copyright
© 2020, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

risenwbib
TY  - CONF
AU  - T.R. Usacheva
AU  - D.N. Kabirov
AU  - Lan Pham Thi
AU  - E.L. Isaeva
AU  - E.R. Aslambekova
AU  - Z.S. Hasbulatova
PY  - 2020
DA  - 2020/10/03
TI  - Inclusion Complexes of Cyclodextrins With Biologically Active Molecules in Water-Organic Solvents as a Promising Material for the Pharmaceutic Industry
BT  - Proceedings of the International Conference “Health and wellbeing in modern society” (ICHW 2020)
PB  - Atlantis Press
SP  - 176
EP  - 182
SN  - 2468-5739
UR  - https://doi.org/10.2991/ahsr.k.201001.036
DO  - 10.2991/ahsr.k.201001.036
ID  - Usacheva2020
ER  -